STANDARD_NAME AMIT_SERUM_RESPONSE_240_MCF10A SYSTEMATIC_NAME M2777 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/AMIT_SERUM_RESPONSE_240_MCF10A NAMESPACE AFFY_HG_U133 DESCRIPTION_BRIEF Genes whose expression peaked at 240 min after stimulation of MCF10A cells with serum. DESCRIPTION_FULL Signaling pathways invoke interplays between forward signaling and feedback to drive robust cellular response. In this study, we address the dynamics of growth factor signaling through profiling of protein phosphorylation and gene expression, demonstrating the presence of a kinetically defined cluster of delayed early genes that function to attenuate the early events of growth factor signaling. Using epidermal growth factor receptor signaling as the major model system and concentrating on regulation of transcription and mRNA stability, we demonstrate that a number of genes within the delayed early gene cluster function as feedback regulators of immediate early genes. Consistent with their role in negative regulation of cell signaling, genes within this cluster are downregulated in diverse tumor types, in correlation with clinical outcome. More generally, our study proposes a mechanistic description of the cellular response to growth factors by defining architectural motifs that underlie the function of signaling networks. PMID 17322878 GEOID GSE6783,GSE6784,GSE6786 AUTHORS Amit I,Citri A,Shay T,Lu Y,Katz M,Zhang F,Tarcic G,Siwak D,Lahad J,Jacob-Hirsch J,Amariglio N,Vaisman N,Segal E,Rechavi G,Alon U,Mills GB,Domany E,Yarden Y CONTRIBUTOR Leona Saunders CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 1S: Part-5 serum peak 240 min FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 200670_at,201107_s_at,201108_s_at,201109_s_at,201130_s_at,201389_at,202270_at,202525_at,202627_s_at,202628_s_at,203092_at,203149_at,203180_at,203652_at,203781_at,203840_at,204221_x_at,204602_at,204614_at,204618_s_at,204693_at,204924_at,204948_s_at,205016_at,205032_at,205172_x_at,205534_at,205595_at,205730_s_at,206008_at,206170_at,207717_s_at,208084_at,208621_s_at,208622_s_at,209386_at,209536_s_at,209651_at,209772_s_at,209803_s_at,209925_at,210517_s_at,210540_s_at,212312_at,212412_at,212978_at,213348_at,213680_at,213895_at,214085_x_at,214168_s_at,214580_x_at,214581_x_at,215068_s_at,217168_s_at,218182_s_at,218292_s_at,218501_at,218634_at,218706_s_at,218856_at,219225_at,219326_s_at,221009_s_at GENE_SYMBOLS ,THBS1,THBS1,THBS1,CDH1,ITGA5,GBP1,PRSS8,SERPINE1,SERPINE1,TIMM44,NECTIN2,ALDH1A3,MAP3K11,MRPL33,BLZF1,GLIPR1,DKK1,SERPINB2,GABPB1,CDC42EP1,TLR2,FST,TGFA,ITGA2,CLTB,PCDH7,DSG3,ABLIM3,TGM1,ADRB2,PKP2,ITGB6,EZR,EZR,TM4SF1,EHD4,TGFB1I1,CD24P4,PHLDA2,OCLNP1,AKAP12,B4GALT4,BCL2L1,PDLIM5,LRRC8B,CDKN1C,KRT6B,EMP1,GLIPR1,TJP1,KRT6A,TNFRSF21,FBXL18,HERPUD1,CLDN1,PRKAG2,ARHGEF3,PHLDA3,GRAMD2B,TNFRSF21,PGBD5,B3GNT2,ANGPTL4 FOUNDER_NAMES