STANDARD_NAME AMUNDSON_GENOTOXIC_SIGNATURE SYSTEMATIC_NAME M10949 COLLECTION ARCHIVED:C2_CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/AMUNDSON_GENOTOXIC_SIGNATURE NAMESPACE UniGene_ID DESCRIPTION_BRIEF Genes discriminating genotoxic (DNA damaging) agents from other kinds of stresses. DESCRIPTION_FULL Gene expression responses of human cell lines exposed to a diverse set of stress agents were compared by cDNA microarray hybridization. The B-lymphoblastoid cell line TK6 (p53 wild-type) and its p53-null derivative, NH32, were treated in parallel to facilitate investigation of p53-dependent responses. RNA was extracted 4 h after the beginning of treatment when no notable decrease in cell viability was evident in the cultures. Gene expression signatures were defined that discriminated between four broad general mechanisms of stress agents: Non-DNA-damaging stresses (heat shock, osmotic shock, and 12-O-tetradecanoylphorbol 13-acetate), agents causing mainly oxidative stress (arsenite and hydrogen peroxide), ionizing radiations (neutron and gamma-ray exposures), and other DNA-damaging agents (ultraviolet radiation, methyl methanesulfonate, adriamycin, camptothecin, and cis-Platinum(II)diammine dichloride (cisplatin)). Within this data set, non-DNA-damaging stresses could be discriminated from all DNA-damaging stresses, and profiles for individual agents were also defined. While DNA-damaging stresses showed a strong p53-dependent element in their responses, no discernible p53-dependent responses were triggered by the non-DNA-damaging stresses. A set of 16 genes did exhibit a robust p53-dependent pattern of induction in response to all nine DNA-damaging agents, however. PMID 15824734 GEOID AUTHORS Amundson SA,Do KT,Vinikoor L,Koch-Paiz CA,Bittner ML,Trent JM,Meltzer P,Fornace AJ Jr CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 4S FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS Hs.102866,Hs.104576,Hs.106730,Hs.112058,Hs.118354,Hs.11899,Hs.121575,Hs.1274,Hs.13318,Hs.143736,Hs.147433,Hs.149413,Hs.1497,Hs.153381,Hs.155040,Hs.159118,Hs.1594,Hs.159557,Hs.164410,Hs.18676,Hs.197071,Hs.198998,Hs.202453,Hs.212606,Hs.2128,Hs.23642,Hs.241570,Hs.243564,Hs.250822,Hs.2556,Hs.25647,Hs.25829,Hs.268557,Hs.268785,Hs.27239,Hs.276925,Hs.279522,Hs.292472,Hs.292524,Hs.300624,Hs.301865,Hs.30213,Hs.304475,Hs.308628,Hs.326035,Hs.351474,Hs.361323,Hs.365706,Hs.36708,Hs.369056,Hs.374097,Hs.3745,Hs.374950,Hs.400740,Hs.404741,Hs.406266,Hs.411472,Hs.424484,Hs.425104,Hs.42650,Hs.431092,Hs.438231,Hs.440955,Hs.444409,Hs.445758,Hs.446564,Hs.449970,Hs.458462,Hs.458917,Hs.459211,Hs.460558,Hs.466791,Hs.468864,Hs.469116,Hs.469649,Hs.474217,Hs.483486,Hs.484885,Hs.496459,Hs.501629,Hs.508343,Hs.509140,Hs.511748,Hs.511987,Hs.512305,Hs.513430,Hs.514368,Hs.515122,Hs.516790,Hs.517782,Hs.519445,Hs.522699,Hs.525324,Hs.529038,Hs.533040,Hs.533474,Hs.534312,Hs.67928,Hs.73172,Hs.77783,Hs.79022,Hs.79411,Hs.80720,Hs.87191,Hs.90791,Hs.95008,Hs.96103,Hs.99120 GENE_SYMBOLS ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, FOUNDER_NAMES