STANDARD_NAME AZARE_STAT3_TARGETS SYSTEMATIC_NAME M2312 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/AZARE_STAT3_TARGETS NAMESPACE AFFY_HG_U133 DESCRIPTION_BRIEF Genes up-regulated in RPWE-1 cells by activated STAT3 [GeneID=6774]. DESCRIPTION_FULL The persistent activation of signal transducer and activator of transcription 3 (Stat3) is a common feature of prostate cancer. However, little is known about the Stat3 targets that may mediate prostate tumorigenesis. The introduction of an activating mutant form of Stat3 (Stat3-C) into immortalized prostate epithelial cells resulted in tumorigenesis. Stat3-C-expressing cells had decreased E-cadherin levels, increased numbers of lamellipodia and stress fibers, and enhanced migratory capacities compared to vector control-expressing cells, with a concomitant increase in the expression of integrin beta6 and its ligand, fibronectin (FN). Exogenously added FN increased cellular migration, with a concomitant loss of E-cadherin expression. The blockade of integrin alphavbeta6 in Stat3-C-expressing cells inhibited migration, increased E-cadherin levels, and reduced colony formation in soft agar. These results demonstrate the sufficiency of constitutively activated Stat3 in mediating prostate tumorigenesis and identify novel Stat3 targets that are involved in promoting cell migration and transformation. PMID 17438134 GEOID AUTHORS Azare J,Leslie K,Al-Ahmadie H,Gerald W,Weinreb PH,Violette SM,Bromberg J CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 2S: FoldChange > 0 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 200796_s_at,200952_s_at,201107_s_at,201211_s_at,201559_s_at,201645_at,202237_at,202238_s_at,203535_at,205534_at,205828_at,206108_s_at,206383_s_at,206474_at,207993_s_at,208083_s_at,208084_at,211194_s_at,211195_s_at,211834_s_at,212105_s_at,213548_s_at,214007_s_at,214336_s_at,214701_s_at,214962_s_at,216627_s_at,217601_at GENE_SYMBOLS MCL1,CCND2,THBS1,DDX3X,CLIC4,TNC,NNMT,NNMT,S100A9,PCDH7,MMP3,SRSF6,G3BP2,CDK17,CHP1,ITGB6,ITGB6,TP63,TP63,TP63,DHX9,CDV3,TWF1,COPA,FN1,NUP160,B4GALT1,NUP188 FOUNDER_NAMES