STANDARD_NAME	BARIS_THYROID_CANCER_UP
SYSTEMATIC_NAME	M2837
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BARIS_THYROID_CANCER_UP
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes up-regulated in oncocytic follicular carcinoma (FTC) vs mitochondrial-rich papillary carcinoma (PTC) types of thyroid cancer.
DESCRIPTION_FULL	The oncogenic pathways in mitochondrial-rich thyroid carcinomas are not clearly understood. To investigate the possible implication of mitochondrial abundance in the genesis of thyroid tumors, we have explored the gene expression profile of six oncocytic carcinomas and six mitochondrial-rich papillary carcinomas using cDNA-microarray technology. A supervised approach allowed us to identify 83 genes differentially expressed in the two types of carcinoma. These genes were classified according to their ontologic profiles. Three genes, NOS3, alpha-actinin-2 and alpha-catenin, suspected of playing a role in tumor genesis, were explored by quantitative RT-PCR analysis and immunohistochemistry. Of the 59 genes overexpressed in papillary carcinomas, 51% were involved in cell communication. Of the 24 genes overexpressed in oncocytic carcinomas, 84% were involved in mitochondrial and cellular metabolism. Our results suggest that mitochondrial respiratory chain complexes III and IV play a significant role in the regulation of reactive oxygen species production by oncocytic tumors.
PMID	15806164
GEOID	
AUTHORS	Baris O,Mirebeau-Prunier D,Savagner F,Rodien P,Ballester B,Loriod B,Granjeaud S,Guyetant S,Franc B,Houlgatte R,Reynier P,Malthiery Y
CONTRIBUTOR	Arthur Liberzon
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 1
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ACTN2,ADA,ATF4,ATP6V1D,COPB,COX6A1,COX7A2,COX7B,CRNKL1,CYC1,CYCS,EIF2S2,ERCC5,GCHFR,GLUL,GSTM3,KIAA0205,MCP,NRF1,PTPRN,RBBP5,RPN1,STIP1,U5-200KD
GENE_SYMBOLS	ACTN2,ADA,ATF4,ATP6V1D,COPB1,COX6A1,COX7A2,COX7B,CRNKL1,CYC1,CYCS,EIF2S2,ERCC5,GCHFR,GLUL,GSTM3,LPGAT1,CD46,NRF1,PTPRN,RBBP5,RPN1,STIP1,SNRNP200
FOUNDER_NAMES