STANDARD_NAME	BARRIER_COLON_CANCER_RECURRENCE_DN
SYSTEMATIC_NAME	M5736
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BARRIER_COLON_CANCER_RECURRENCE_DN
NAMESPACE	AFFY_HG_U133
DESCRIPTION_BRIEF	Down-regulated genes from the 70-gene prognosis predictor for stage 2 colon cancer, based on non-neoplastic mucosa gene expression profiles.
DESCRIPTION_FULL	We have assessed the possibility to build a prognosis predictor (PP), based on non-neoplastic mucosa microarray gene expression measures, for stage II colon cancer patients. Non-neoplastic colonic mucosa mRNA samples from 24 patients (10 with a metachronous metastasis, 14 with no recurrence) were profiled using the Affymetrix HGU133A GeneChip. Patients were repeatedly and randomly divided into 1000 training sets (TSs) of size 16 and validation sets (VS) of size 8. For each TS/VS split, a 70-gene PP, identified on the TS by selecting the 70 most differentially expressed genes and applying diagonal linear discriminant analysis, was used to predict the prognoses of VS patients. Mean prognosis prediction performances of the 70-gene PP were 81.8% for accuracy, 73.0% for sensitivity and 87.1% for specificity. Informative genes suggested branching signal-transduction pathways with possible extensive networks between individual pathways. They also included genes coding for proteins involved in immune surveillance. In conclusion, our study suggests that one can build an accurate PP for stage II colon cancer patients, based on non-neoplastic mucosa microarray gene expression measures.
PMID	17043639
GEOID	
AUTHORS	Barrier A,Roser F,Boëlle PY,Franc B,Tse C,Brault D,Lacaine F,Houry S,Callard P,Penna C,Debuire B,Flahault A,Dudoit S,Lemoine A
CONTRIBUTOR	Arthur Liberzon
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 5
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	200646_s_at,200661_at,202242_at,205170_at,207722_s_at,207980_s_at,208156_x_at,208651_x_at,208677_s_at,209357_at,209771_x_at,210079_x_at,210622_x_at,211065_x_at,211799_x_at,213827_at,215833_s_at,216103_at,216379_x_at,217310_s_at,217729_s_at,217800_s_at,218862_at,266_s_at
GENE_SYMBOLS	NUCB1,CTSA,TSPAN7,STAT2,BTBD2,CITED2,EPPK1,CD24,BSG,CITED2,CD24,KCNAB1,CDK10,PFKL,,ARHGAP33,SPPL2B,ACOT11,CD24,FOXJ3,TLE5,NDFIP1,ASB13,CD24
FOUNDER_NAMES