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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="BILBAN_B_CLL_LPL_UP" SYSTEMATIC_NAME="M19930" HISTORICAL_NAMES="" PMID="16617321" AUTHORS="Bilban M,Heintel D,Scharl T,Woelfel T,Auer MM,Porpaczy E,Kainz B,Kröber A,Carey VJ,Shehata M,Zielinski C,Pickl W,Stilgenbauer S,Gaiger A,Wagner O,Jäger U,German CLL Study Group" GEOID="" EXACT_SOURCE="Table 1AS" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="AFFY_HG_U133" CONTRIBUTOR="Arthur Liberzon" CONTRIBUTOR_ORG="MSigDB Team" DESCRIPTION_BRIEF="Genes up-regulated in B-CLL (B-cell chronic leukemia) samples expressing high levels of LPL [GeneID=4023] compared with those expressing low levels of the gene." DESCRIPTION_FULL="Lipoprotein lipase (LPL) is a prognostic marker in B-cell chronic lymphocytic leukemia (B-CLL) related to immunoglobulin V(H) gene (IgV(H))mutational status. We determined gene expression profiles using Affymetrix U133A GeneChips in two groups of B-CLLs selected for either high ('LPL+', n=10) or low ('LPL-', n=10) LPL mRNA expression. Selected genes were verified by real-time PCR in an extended patient cohort (n=42). A total of 111 genes discriminated LPL+ from LPL- B-CLLs. Of these, the top three genes associated with time to first treatment were Septin10, DMD and Gravin (P&lt;/=0.01). The relationship of LPL+ and LPL- B-CLL gene expression signatures to 52 tissues was statistically analyzed. The LPL+ B-CLL expression signature, represented by 64 genes was significantly related to fat, muscle and PB dendritic cells (P&lt;0.001). Exploration of microarray data to define functional alterations related to the biology of LPL+ CLL identified two functional modules, fatty acid degradation and MTA3 signaling, as being altered with higher statistical significance. Our data show that LPL+ B-CLL cells have not only acquired gene expression changes in fat and muscle-associated genes but also in functional pathways related to fatty acid degradation and signaling which may ultimately influence CLL biology and clinical outcome." TAGS="" MEMBERS="201204_s_at,201206_s_at,201710_at,201760_s_at,201772_at,202395_at,202421_at,202981_x_at,203143_s_at,203404_at,203406_at,203454_s_at,203548_s_at,203549_s_at,203633_at,203695_s_at,203795_s_at,203796_s_at,203881_s_at,204072_s_at,204513_s_at,204562_at,204688_at,204866_at,204972_at,205263_at,205484_at,205552_s_at,205704_s_at,206337_at,206759_at,206760_s_at,208613_s_at,208614_s_at,208900_s_at,209193_at,209236_at,209455_at,209498_at,209598_at,209854_s_at,210279_at,210517_s_at,211645_x_at,212092_at,212094_at,212110_at,212345_s_at,212350_at,212503_s_at,212504_at,212671_s_at,212698_s_at,212812_at,212838_at,213674_x_at,213689_x_at,214908_s_at,214971_s_at,215621_s_at,216044_x_at,216607_s_at,216724_at,217504_at,218096_at,218418_s_at,218594_at,218968_s_at,218999_at,219496_at,220146_at,221234_s_at,221479_s_at,221551_x_at" MEMBERS_SYMBOLIZED="ABCA6,AGPAT5,AKAP12,ARMCX2,ATOX1,ATP6V0A2,AZIN1,BACH2,BCL10,BCL7A,BNIP3L,CCR7,CEACAM1,CPT1A,CREB3L2,CYP51A1,DIP2C,DIPK1A,DMD,DNMBP,ELMO1,FBXW11,FCER2,FLNB,FRY,GPR18,GSDME,HEATR1,HLA-DQA1,IGHD,IGKV1D-17,IGSF3,IRF4,JADE3,KANK2,KIAA0040,KLK2,LPL,MFAP1,MYBL2,NSF,OAS1,OAS2,PEG10,PIM1,PNMA2,RRBP1,SEPTIN10,SERINC5,SGCE,SIAH1,SIT1,SLC23A2,SLC39A14,SOWAHC,ST6GAL1,ST6GALNAC4,TBC1D1,TLR7,TMEM140,TOP1,TRRAP,WSB2,ZFP64" MEMBERS_EZID="10129,10687,1236,1374,151011,1595,1687,1756,2208,22982,23089,2317,23216,23268,23291,23460,23516,23545,256987,25959,27090,27240,2841,28900,3117,3321,3495,3662,3817,388650,4023,4236,4605,475,4905,4938,4939,51284,51582,5292,55127,55281,55326,55734,55884,60468,605,6238,634,64764,6477,6480,65124,665,7150,8295,8910,8915,9590,9674,9767,9823,9844,9962" MEMBERS_MAPPING="201204_s_at,RRBP1,6238|201206_s_at,RRBP1,6238|201710_at,MYBL2,4605|201760_s_at,WSB2,55884|201772_at,AZIN1,51582|202395_at,NSF,4905|202421_at,IGSF3,3321|202981_x_at,SIAH1,6477|203143_s_at,KIAA0040,9674|203404_at,ARMCX2,9823|203406_at,MFAP1,4236|203454_s_at,ATOX1,475|203548_s_at,LPL,4023|203549_s_at,LPL,4023|203633_at,CPT1A,1374|203695_s_at,GSDME,1687|203795_s_at,BCL7A,605|203796_s_at,BCL7A,605|203881_s_at,DMD,1756|204072_s_at,FRY,10129|204513_s_at,ELMO1,9844|204562_at,IRF4,3662|204688_at,SGCE,8910|204866_at,JADE3,9767|204972_at,OAS2,4939|205263_at,BCL10,8915|205484_at,SIT1,27240|205552_s_at,OAS1,4938|205704_s_at,ATP6V0A2,23545|206337_at,CCR7,1236|206759_at,FCER2,2208|206760_s_at,FCER2,2208|208613_s_at,FLNB,2317|208614_s_at,FLNB,2317|208900_s_at,TOP1,7150|209193_at,PIM1,5292|209236_at,SLC23A2,9962|209455_at,FBXW11,23291|209498_at,CEACAM1,634|209598_at,PNMA2,10687|209854_s_at,KLK2,3817|210279_at,GPR18,2841|210517_s_at,AKAP12,9590|211645_x_at,IGKV1D-17,28900|212092_at,PEG10,23089|212094_at,PEG10,23089|212110_at,SLC39A14,23516|212345_s_at,CREB3L2,64764|212350_at,TBC1D1,23216|212503_s_at,DIP2C,22982|212504_at,DIP2C,22982|212671_s_at,HLA-DQA1,3117|212698_s_at,SEPTIN10,151011|212812_at,SERINC5,256987|212838_at,DNMBP,23268|213674_x_at,IGHD,3495|213689_x_at,DIPK1A,388650|214908_s_at,TRRAP,8295|214971_s_at,ST6GAL1,6480|215621_s_at,IGHD,3495|216044_x_at,DIPK1A,388650|216607_s_at,CYP51A1,1595|216724_at,null,null|217504_at,ABCA6,23460|218096_at,AGPAT5,55326|218418_s_at,KANK2,25959|218594_at,HEATR1,55127|218968_s_at,ZFP64,55734|218999_at,TMEM140,55281|219496_at,SOWAHC,65124|220146_at,TLR7,51284|221234_s_at,BACH2,60468|221479_s_at,BNIP3L,665|221551_x_at,ST6GALNAC4,27090" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CGP"/>
</MSIGDB>
