STANDARD_NAME	BIOCARTA_AKT_PATHWAY
SYSTEMATIC_NAME	M15258
COLLECTION	C2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_AKT_PATHWAY
NAMESPACE	HUMAN_SEQ_ACCESSION
DESCRIPTION_BRIEF	AKT Signaling Pathway
DESCRIPTION_FULL	Many cell-surface receptors induce production of second messengers like PIP3, phosphatidylinositol 3,4,5-trisphosphate, that convey signals to the cytoplasm from the cell surface. PIP3 signals activates the kinase PDK1, 3-phosphoinositide-dependent protein kinase-1, which in turn activates the kinase AKT, also known as protein kinase B. Proteins phosphorylated by activated AKT promote cell survival. Phosphorylation of Ikappa-B kinase leads to activation of the transcription factor NF-kB to oppose apoptosis. Bad is a protein in the Bcl-2 gene family that opposes Bcl-2 to induce apoptosis. Phosphorylation of Bad by AKT blocks anti-apoptotic activity to promote cell survival. Similarly, phosphorylation of the protease caspase 9 or forkhead transcription factors by AKT block the induction of apoptosis by these factors. AKT promotes cell survival and opposes apoptosis by a variety of routes.
PMID	
GEOID	
AUTHORS	
CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_aktPathway.gif
SOURCE_MEMBERS	AI334281,AK021510,BM458681,HY197260,NM_000163,NM_000515,NM_000639,NM_001014431,NM_001014432,NM_001017963,NM_001099856,NM_001099857,NM_001145138,NM_001145255,NM_001165412,NM_001170931,NM_001190720,NM_001229,NM_001242399,NM_001242400,NM_001242401,NM_001242402,NM_001242403,NM_001242404,NM_001242405,NM_001242406,NM_001242460,NM_001242461,NM_001242462,NM_001242466,NM_001242778,NM_001243984,NM_001243985,NM_001261816,NM_001278,NM_001455,NM_001556,NM_002015,NM_002613,NM_002649,NM_002715,NM_003405,NM_003639,NM_003998,NM_004322,NM_005163,NM_005348,NM_005938,NM_006218,NM_020529,NM_021975,NM_022559,NM_022560,NM_022561,NM_022562,NM_031268,NM_032989,NM_032996,NM_181504,NM_181523,NM_181524,NM_201559,Z11851
GENE_SYMBOLS	PIK3R1,PIK3CA,,GHR,GHR,GH1,FASLG,AKT1,AKT1,HSP90AA1,IKBKG,IKBKG,RELA,IKBKG,NFKB1,FOXO4,IKBKB,CASP9,GHR,GHR,GHR,GHR,GHR,GHR,GHR,GHR,GHR,GHR,GHR,PIK3R1,IKBKB,RELA,RELA,PDPK1,CHUK,FOXO3,IKBKB,FOXO1,PDPK1,PIK3CG,PPP2CA,YWHAH,IKBKG,NFKB1,BAD,AKT1,HSP90AA1,FOXO4,PIK3CA,NFKBIA,RELA,GH1,GH1,GH1,GH1,PDPK1,BAD,CASP9,PIK3R1,PIK3R1,PIK3R1,FOXO3,GHR
FOUNDER_NAMES