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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="BIOCARTA_AKT_PATHWAY" SYSTEMATIC_NAME="M15258" HISTORICAL_NAMES="" PMID="" AUTHORS="" GEOID="" EXACT_SOURCE="" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_aktPathway.gif" CHIP="HUMAN_SEQ_ACCESSION" CONTRIBUTOR="BioCarta" CONTRIBUTOR_ORG="BioCarta" DESCRIPTION_BRIEF="AKT Signaling Pathway" DESCRIPTION_FULL="Many cell-surface receptors induce production of second messengers like PIP3, phosphatidylinositol 3,4,5-trisphosphate, that convey signals to the cytoplasm from the cell surface. PIP3 signals activates the kinase PDK1, 3-phosphoinositide-dependent protein kinase-1, which in turn activates the kinase AKT, also known as protein kinase B. Proteins phosphorylated by activated AKT promote cell survival. Phosphorylation of Ikappa-B kinase leads to activation of the transcription factor NF-kB to oppose apoptosis. Bad is a protein in the Bcl-2 gene family that opposes Bcl-2 to induce apoptosis. Phosphorylation of Bad by AKT blocks anti-apoptotic activity to promote cell survival. Similarly, phosphorylation of the protease caspase 9 or forkhead transcription factors by AKT block the induction of apoptosis by these factors. AKT promotes cell survival and opposes apoptosis by a variety of routes." TAGS="" MEMBERS="AI334281,AK021510,BM458681,HY197260,NM_000163,NM_000515,NM_000639,NM_001014431,NM_001014432,NM_001017963,NM_001099856,NM_001099857,NM_001145138,NM_001145255,NM_001165412,NM_001170931,NM_001190720,NM_001229,NM_001242399,NM_001242400,NM_001242401,NM_001242402,NM_001242403,NM_001242404,NM_001242405,NM_001242406,NM_001242460,NM_001242461,NM_001242462,NM_001242466,NM_001242778,NM_001243984,NM_001243985,NM_001261816,NM_001278,NM_001455,NM_001556,NM_002015,NM_002613,NM_002649,NM_002715,NM_003405,NM_003639,NM_003998,NM_004322,NM_005163,NM_005348,NM_005938,NM_006218,NM_020529,NM_021975,NM_022559,NM_022560,NM_022561,NM_022562,NM_031268,NM_032989,NM_032996,NM_181504,NM_181523,NM_181524,NM_201559,Z11851" MEMBERS_SYMBOLIZED="AKT1,BAD,CASP9,CHUK,FASLG,FOXO1,FOXO3,FOXO4,GH1,GHR,HSP90AA1,IKBKB,IKBKG,NFKB1,NFKBIA,PDPK1,PIK3CA,PIK3CG,PIK3R1,PPP2CA,RELA,YWHAH" MEMBERS_EZID="1147,207,2308,2309,2688,2690,3320,3551,356,4303,4790,4792,5170,5290,5294,5295,5515,572,5970,7533,842,8517" MEMBERS_MAPPING="AI334281,PIK3R1,5295|AK021510,PIK3CA,5290|BM458681,null,null|HY197260,GHR,2690|NM_000163,GHR,2690|NM_000515,GH1,2688|NM_000639,FASLG,356|NM_001014431,AKT1,207|NM_001014432,AKT1,207|NM_001017963,HSP90AA1,3320|NM_001099856,IKBKG,8517|NM_001099857,IKBKG,8517|NM_001145138,RELA,5970|NM_001145255,IKBKG,8517|NM_001165412,NFKB1,4790|NM_001170931,FOXO4,4303|NM_001190720,IKBKB,3551|NM_001229,CASP9,842|NM_001242399,GHR,2690|NM_001242400,GHR,2690|NM_001242401,GHR,2690|NM_001242402,GHR,2690|NM_001242403,GHR,2690|NM_001242404,GHR,2690|NM_001242405,GHR,2690|NM_001242406,GHR,2690|NM_001242460,GHR,2690|NM_001242461,GHR,2690|NM_001242462,GHR,2690|NM_001242466,PIK3R1,5295|NM_001242778,IKBKB,3551|NM_001243984,RELA,5970|NM_001243985,RELA,5970|NM_001261816,PDPK1,5170|NM_001278,CHUK,1147|NM_001455,FOXO3,2309|NM_001556,IKBKB,3551|NM_002015,FOXO1,2308|NM_002613,PDPK1,5170|NM_002649,PIK3CG,5294|NM_002715,PPP2CA,5515|NM_003405,YWHAH,7533|NM_003639,IKBKG,8517|NM_003998,NFKB1,4790|NM_004322,BAD,572|NM_005163,AKT1,207|NM_005348,HSP90AA1,3320|NM_005938,FOXO4,4303|NM_006218,PIK3CA,5290|NM_020529,NFKBIA,4792|NM_021975,RELA,5970|NM_022559,GH1,2688|NM_022560,GH1,2688|NM_022561,GH1,2688|NM_022562,GH1,2688|NM_031268,PDPK1,5170|NM_032989,BAD,572|NM_032996,CASP9,842|NM_181504,PIK3R1,5295|NM_181523,PIK3R1,5295|NM_181524,PIK3R1,5295|NM_201559,FOXO3,2309|Z11851,GHR,2690" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CP:BIOCARTA"/>
</MSIGDB>
