STANDARD_NAME	BIOCARTA_ATM_PATHWAY
SYSTEMATIC_NAME	M10628
COLLECTION	C2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_ATM_PATHWAY
NAMESPACE	HUMAN_SEQ_ACCESSION
DESCRIPTION_BRIEF	ATM Signaling Pathway
DESCRIPTION_FULL	The ataxia telangiectasia-mutated gene (ATM) encodes a protein kinase that acts as a tumor suppressor. ATM activation by ionizing radiation damage to DNA stimulates DNA repair and blocks progression through the cell cycle. Mutation of the ATM gene causes the disease ataxia telangiectasia which which involves an inherited predisposition to some cancers. To play this role ATM interacts with a broad network of proteins, including checkpoint factors (chk1, chk2), tumor suppressors (p53 and BRCA), DNA repair factors (RAD50, RAD51, GADD45), and other signaling molecules (c-Abl and NF-kB). In addition to regulating DNA repair and the cell cycle, ATM can also trigger apoptosis in radiation treated cells.
PMID	
GEOID	
AUTHORS	
CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_atmPathway.gif
SOURCE_MEMBERS	BM469215,BM551246,BM665433,BM670623,BP420084,JX015388,NM_000051,NM_000389,NM_000546,NM_001005735,NM_001114121,NM_001114122,NM_001126112,NM_001126113,NM_001126114,NM_001126115,NM_001126116,NM_001126117,NM_001126118,NM_001126240,NM_001126241,NM_001126242,NM_001145138,NM_001164269,NM_001164270,NM_001165412,NM_001199741,NM_001199742,NM_001204184,NM_001204185,NM_001204186,NM_001204187,NM_001204188,NM_001204189,NM_001204190,NM_001204191,NM_001204192,NM_001220777,NM_001220778,NM_001243984,NM_001243985,NM_001244846,NM_001257387,NM_001274,NM_001924,NM_002228,NM_002392,NM_002485,NM_002750,NM_002875,NM_002894,NM_003998,NM_005157,NM_005427,NM_005590,NM_005591,NM_005732,NM_007194,NM_007294,NM_007297,NM_007298,NM_007299,NM_007300,NM_007313,NM_020529,NM_021975,NM_078467,NM_133487,NM_139046,NM_139047,NM_139049,NM_145862,NM_203291,NM_203292
GENE_SYMBOLS	TP53,,,,,MDM2,ATM,CDKN1A,TP53,CHEK2,CHEK1,CHEK1,TP53,TP53,TP53,TP53,TP53,TP53,TP53,TP73,TP73,TP73,RELA,RAD51,RAD51,NFKB1,GADD45A,GADD45A,TP73,TP73,TP73,TP73,TP73,TP73,TP73,TP73,TP73,CDKN1A,CDKN1A,RELA,RELA,CHEK1,CHEK2,CHEK1,GADD45A,JUN,MDM2,NBN,MAPK8,RAD51,RBBP8,NFKB1,ABL1,TP73,MRE11,MRE11,RAD50,CHEK2,BRCA1,BRCA1,BRCA1,BRCA1,BRCA1,ABL1,NFKBIA,RELA,CDKN1A,RAD51,MAPK8,,MAPK8,CHEK2,RBBP8,RBBP8
FOUNDER_NAMES