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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="BIOCARTA_ATM_PATHWAY" SYSTEMATIC_NAME="M10628" HISTORICAL_NAMES="" PMID="" AUTHORS="" GEOID="" EXACT_SOURCE="" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_atmPathway.gif" CHIP="HUMAN_SEQ_ACCESSION" CONTRIBUTOR="BioCarta" CONTRIBUTOR_ORG="BioCarta" DESCRIPTION_BRIEF="ATM Signaling Pathway" DESCRIPTION_FULL="The ataxia telangiectasia-mutated gene (ATM) encodes a protein kinase that acts as a tumor suppressor. ATM activation by ionizing radiation damage to DNA stimulates DNA repair and blocks progression through the cell cycle. Mutation of the ATM gene causes the disease ataxia telangiectasia which which involves an inherited predisposition to some cancers. To play this role ATM interacts with a broad network of proteins, including checkpoint factors (chk1, chk2), tumor suppressors (p53 and BRCA), DNA repair factors (RAD50, RAD51, GADD45), and other signaling molecules (c-Abl and NF-kB). In addition to regulating DNA repair and the cell cycle, ATM can also trigger apoptosis in radiation treated cells." TAGS="" MEMBERS="BM469215,BM551246,BM665433,BM670623,BP420084,JX015388,NM_000051,NM_000389,NM_000546,NM_001005735,NM_001114121,NM_001114122,NM_001126112,NM_001126113,NM_001126114,NM_001126115,NM_001126116,NM_001126117,NM_001126118,NM_001126240,NM_001126241,NM_001126242,NM_001145138,NM_001164269,NM_001164270,NM_001165412,NM_001199741,NM_001199742,NM_001204184,NM_001204185,NM_001204186,NM_001204187,NM_001204188,NM_001204189,NM_001204190,NM_001204191,NM_001204192,NM_001220777,NM_001220778,NM_001243984,NM_001243985,NM_001244846,NM_001257387,NM_001274,NM_001924,NM_002228,NM_002392,NM_002485,NM_002750,NM_002875,NM_002894,NM_003998,NM_005157,NM_005427,NM_005590,NM_005591,NM_005732,NM_007194,NM_007294,NM_007297,NM_007298,NM_007299,NM_007300,NM_007313,NM_020529,NM_021975,NM_078467,NM_133487,NM_139046,NM_139047,NM_139049,NM_145862,NM_203291,NM_203292" MEMBERS_SYMBOLIZED="ABL1,ATM,BRCA1,CDKN1A,CHEK1,CHEK2,GADD45A,JUN,MAPK8,MDM2,MRE11,NBN,NFKB1,NFKBIA,RAD50,RAD51,RBBP8,RELA,TP53,TP73" MEMBERS_EZID="10111,1026,1111,11200,1647,25,3725,4193,4361,4683,472,4790,4792,5599,5888,5932,5970,672,7157,7161" MEMBERS_MAPPING="BM469215,TP53,7157|BM551246,null,null|BM665433,null,null|BM670623,null,null|BP420084,null,null|JX015388,MDM2,4193|NM_000051,ATM,472|NM_000389,CDKN1A,1026|NM_000546,TP53,7157|NM_001005735,CHEK2,11200|NM_001114121,CHEK1,1111|NM_001114122,CHEK1,1111|NM_001126112,TP53,7157|NM_001126113,TP53,7157|NM_001126114,TP53,7157|NM_001126115,TP53,7157|NM_001126116,TP53,7157|NM_001126117,TP53,7157|NM_001126118,TP53,7157|NM_001126240,TP73,7161|NM_001126241,TP73,7161|NM_001126242,TP73,7161|NM_001145138,RELA,5970|NM_001164269,RAD51,5888|NM_001164270,RAD51,5888|NM_001165412,NFKB1,4790|NM_001199741,GADD45A,1647|NM_001199742,GADD45A,1647|NM_001204184,TP73,7161|NM_001204185,TP73,7161|NM_001204186,TP73,7161|NM_001204187,TP73,7161|NM_001204188,TP73,7161|NM_001204189,TP73,7161|NM_001204190,TP73,7161|NM_001204191,TP73,7161|NM_001204192,TP73,7161|NM_001220777,CDKN1A,1026|NM_001220778,CDKN1A,1026|NM_001243984,RELA,5970|NM_001243985,RELA,5970|NM_001244846,CHEK1,1111|NM_001257387,CHEK2,11200|NM_001274,CHEK1,1111|NM_001924,GADD45A,1647|NM_002228,JUN,3725|NM_002392,MDM2,4193|NM_002485,NBN,4683|NM_002750,MAPK8,5599|NM_002875,RAD51,5888|NM_002894,RBBP8,5932|NM_003998,NFKB1,4790|NM_005157,ABL1,25|NM_005427,TP73,7161|NM_005590,MRE11,4361|NM_005591,MRE11,4361|NM_005732,RAD50,10111|NM_007194,CHEK2,11200|NM_007294,BRCA1,672|NM_007297,BRCA1,672|NM_007298,BRCA1,672|NM_007299,BRCA1,672|NM_007300,BRCA1,672|NM_007313,ABL1,25|NM_020529,NFKBIA,4792|NM_021975,RELA,5970|NM_078467,CDKN1A,1026|NM_133487,RAD51,5888|NM_139046,MAPK8,5599|NM_139047,null,null|NM_139049,MAPK8,5599|NM_145862,CHEK2,11200|NM_203291,RBBP8,5932|NM_203292,RBBP8,5932" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CP:BIOCARTA"/>
</MSIGDB>
