STANDARD_NAME	BIOCARTA_BAD_PATHWAY
SYSTEMATIC_NAME	M85
COLLECTION	C2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_BAD_PATHWAY
NAMESPACE	HUMAN_SEQ_ACCESSION
DESCRIPTION_BRIEF	Regulation of BAD phosphorylation
DESCRIPTION_FULL	The function of the pro-apoptotic molecule BAD is regulated by phosphorylation of three sites (ser 112,136 and 155). Phosphorylation at these sites results in loss of the ability of BAD to heterodimerize with the survival proteins BCL-XL or BCL-2. Phosphorylated BAD binds to 14-3-3 and is sequestered in the cytoplasm. While ser-136 phosphorylation is concordant with the activation of Akt, Ser-112 phosphorylation requires activation of the Ras-MAPK pathway. BAD Ser 155 was found to be a major site of phosphorylation induced following stimulation by growth factors and prevented by protein kinase A inhibitors.
PMID	
GEOID	
AUTHORS	
CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_badPathway.gif
SOURCE_MEMBERS	AI334281,AK021510,BC111788,BM458681,CK300639,NM_000222,NM_000395,NM_000588,NM_000618,NM_000633,NM_000657,NM_000875,NM_000899,NM_001006665,NM_001014431,NM_001014432,NM_001040056,NM_001093772,NM_001109891,NM_001111283,NM_001111284,NM_001111285,NM_001164758,NM_001164759,NM_001164760,NM_001164761,NM_001164762,NM_001242466,NM_001242857,NM_001242858,NM_001242859,NM_001242860,NM_001242861,NM_001242862,NM_001267713,NM_002183,NM_002649,NM_002731,NM_002732,NM_002734,NM_002735,NM_002736,NM_002745,NM_002746,NM_002953,NM_003405,NM_003994,NM_004157,NM_004322,NM_004324,NM_005163,NM_006218,NM_021116,NM_032989,NM_138761,NM_138763,NM_138764,NM_138957,NM_181504,NM_181523,NM_181524,NM_182948,NM_207578,NM_212471,NM_212472
GENE_SYMBOLS	PIK3R1,PIK3CA,,,,KIT,CSF2RB,IL3,IGF1,BCL2,BCL2,IGF1R,KITLG,RPS6KA1,AKT1,AKT1,MAPK3,KIT,MAPK3,IGF1,IGF1,IGF1,PRKAR1B,PRKAR1B,PRKAR1B,PRKAR1B,PRKAR1B,PIK3R1,PRKACB,PRKACB,PRKACB,PRKACB,PRKACB,PRKACB,IL3RA,IL3RA,PIK3CG,PRKACB,PRKACG,PRKAR1A,PRKAR1B,PRKAR2B,MAPK1,MAPK3,RPS6KA1,YWHAH,KITLG,PRKAR2A,BAD,BAX,AKT1,PIK3CA,ADCY1,BAD,BAX,BAX,BAX,MAPK1,PIK3R1,PIK3R1,PIK3R1,PRKACB,PRKACB,PRKAR1A,PRKAR1A
FOUNDER_NAMES