STANDARD_NAME	BIOCARTA_BARR_MAPK_PATHWAY
SYSTEMATIC_NAME	M668
COLLECTION	C2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_BARR_MAPK_PATHWAY
NAMESPACE	HUMAN_SEQ_ACCESSION
DESCRIPTION_BRIEF	Role of b-arrestins in the activation and targeting of MAP kinases
DESCRIPTION_FULL	The binding of -arrestins to agonist-occupied GPCRs triggers the assembly of a MAP kinase activation complex using -arrestin as a scaffold, with subsequent activation of a -arrestin-bound pool of ERK1/2. The receptor-arrestinERK complexes are localized to endosomal vesicles, and their formation does not result in nuclear translocation of activated ERK1/2 or stimulation of cell proliferation. The function of -arrestin-bound ERK1/2 is presently unknown. Activation of ERK1/2 by -arrestin scaffolds may favor the phosphorylation of plasma membrane, cytosolic, or cytoskeletal ERK1/2 substrates, or it may lead to transcriptional activation through the ERK-dependent activation of other kinases. The model depicts -arrestin scaffolding of the ERK1/2 MAP kinase cascade, based upon data obtained with the protease-activated PAR2 and angiotensin AT1a receptors. A similar mechanism has been proposed for regulation of the JNK3 MAP kinase cascade by AT1a receptors.
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AUTHORS	
CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_bArr-mapkPathway.gif
SOURCE_MEMBERS	BI907383,CD365891,NM_000217,NM_000516,NM_001005336,NM_001040056,NM_001077488,NM_001077489,NM_001077490,NM_001109891,NM_001204269,NM_001619,NM_002232,NM_002745,NM_002746,NM_002755,NM_002880,NM_004041,NM_004408,NM_004974,NM_015192,NM_016592,NM_020251,NM_021116,NM_030662,NM_080425,NM_080426,NM_138957,NM_182734
GENE_SYMBOLS	KCNA2,ARRB1,KCNA1,GNAS,DNM1,MAPK3,GNAS,GNAS,GNAS,MAPK3,KCNA2,GRK2,KCNA3,MAPK1,MAPK3,MAP2K1,RAF1,ARRB1,DNM1,KCNA2,PLCB1,GNAS,ARRB1,ADCY1,MAP2K2,GNAS,GNAS,MAPK1,PLCB1
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