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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="BIOCARTA_BARR_MAPK_PATHWAY" SYSTEMATIC_NAME="M668" HISTORICAL_NAMES="" PMID="" AUTHORS="" GEOID="" EXACT_SOURCE="" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_bArr-mapkPathway.gif" CHIP="HUMAN_SEQ_ACCESSION" CONTRIBUTOR="BioCarta" CONTRIBUTOR_ORG="BioCarta" DESCRIPTION_BRIEF="Role of b-arrestins in the activation and targeting of MAP kinases" DESCRIPTION_FULL="The binding of -arrestins to agonist-occupied GPCRs triggers the assembly of a MAP kinase activation complex using -arrestin as a scaffold, with subsequent activation of a -arrestin-bound pool of ERK1/2. The receptor-arrestinERK complexes are localized to endosomal vesicles, and their formation does not result in nuclear translocation of activated ERK1/2 or stimulation of cell proliferation. The function of -arrestin-bound ERK1/2 is presently unknown. Activation of ERK1/2 by -arrestin scaffolds may favor the phosphorylation of plasma membrane, cytosolic, or cytoskeletal ERK1/2 substrates, or it may lead to transcriptional activation through the ERK-dependent activation of other kinases. The model depicts -arrestin scaffolding of the ERK1/2 MAP kinase cascade, based upon data obtained with the protease-activated PAR2 and angiotensin AT1a receptors. A similar mechanism has been proposed for regulation of the JNK3 MAP kinase cascade by AT1a receptors." TAGS="" MEMBERS="BI907383,CD365891,NM_000217,NM_000516,NM_001005336,NM_001040056,NM_001077488,NM_001077489,NM_001077490,NM_001109891,NM_001204269,NM_001619,NM_002232,NM_002745,NM_002746,NM_002755,NM_002880,NM_004041,NM_004408,NM_004974,NM_015192,NM_016592,NM_020251,NM_021116,NM_030662,NM_080425,NM_080426,NM_138957,NM_182734" MEMBERS_SYMBOLIZED="ADCY1,ARRB1,DNM1,GNAS,GRK2,KCNA1,KCNA2,KCNA3,MAP2K1,MAP2K2,MAPK1,MAPK3,PLCB1,RAF1" MEMBERS_EZID="107,156,1759,23236,2778,3736,3737,3738,408,5594,5595,5604,5605,5894" MEMBERS_MAPPING="BI907383,KCNA2,3737|CD365891,ARRB1,408|NM_000217,KCNA1,3736|NM_000516,GNAS,2778|NM_001005336,DNM1,1759|NM_001040056,MAPK3,5595|NM_001077488,GNAS,2778|NM_001077489,GNAS,2778|NM_001077490,GNAS,2778|NM_001109891,MAPK3,5595|NM_001204269,KCNA2,3737|NM_001619,GRK2,156|NM_002232,KCNA3,3738|NM_002745,MAPK1,5594|NM_002746,MAPK3,5595|NM_002755,MAP2K1,5604|NM_002880,RAF1,5894|NM_004041,ARRB1,408|NM_004408,DNM1,1759|NM_004974,KCNA2,3737|NM_015192,PLCB1,23236|NM_016592,GNAS,2778|NM_020251,ARRB1,408|NM_021116,ADCY1,107|NM_030662,MAP2K2,5605|NM_080425,GNAS,2778|NM_080426,GNAS,2778|NM_138957,MAPK1,5594|NM_182734,PLCB1,23236" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CP:BIOCARTA"/>
</MSIGDB>
