STANDARD_NAME	BIOCARTA_CARM_ER_PATHWAY
SYSTEMATIC_NAME	M2499
COLLECTION	C2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_CARM_ER_PATHWAY
NAMESPACE	Human_RefSeq
DESCRIPTION_BRIEF	CARM1 and Regulation of the Estrogen Receptor
DESCRIPTION_FULL	Several forms of post-translational modification regulate protein activities. Recently, protein methylation by CARM1 (coactivator-associated arginine methyltransferase 1) has been observed to play a key role in transcriptional regulation. CARM1 associates with the p160 class of transcriptional coactivators involved in gene activation by steroid hormone family receptors. CARM1 also interacts with CBP/p300 transcriptional coactivators involved in gene activation by a large variety of transcription factors, including steroid hormone receptors and CEBP. One target of CARM1 is the core histones H3 and H4, which are also targets of the histone acetylase activity of CBP/p300 coactivators. Recruitment of CARM1 to the promoter region by binding to coactivators increases histone methylation and makes promoter regions more accessible for transcription. Another target of CARM1 methylation is a coactivator it interacts with, CBP. Methylation of CBP by CARM1 blocks CBP from acting as a coactivator for CREB and redirects the limited CBP pool in the cell to be available for steroid hormone receptors. Other forms of post-translational protein modification such as phosphorylation are reversible in nature, but as of yet a protein demethylase is not known. The methylation activity of CARM1 modulates the activity of specific transcriptional regulators. CARM1 acts as a coactivator for the myogenic transcription factor Mef2c, and is necessary for normal muscle cell differentiation. The estrogen receptor is another transcription factor that uses CARM1 as one of several coactivators, acting synergistically with CBP through the Grip1 member of the p160 family of coactivators. The interaction of estrogen receptor with various ligand-dependent coactivators may produce the tissue selective response of some estrogen receptor ligands like tamoxifen.
PMID	
GEOID	
AUTHORS	
CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_carm-erPathway.gif
SOURCE_MEMBERS	NM_000125,NM_000475,NM_001015053,NM_001035235,NM_001077261,NM_001079846,NM_001122740,NM_001122741,NM_001122742,NM_001131005,NM_001144831,NM_001172085,NM_001178074,NM_001193347,NM_001193348,NM_001193349,NM_001193350,NM_001206654,NM_001253764,NM_001267700,NM_001429,NM_001527,NM_002397,NM_003194,NM_003489,NM_003883,NM_004380,NM_004774,NM_004964,NM_005474,NM_006037,NM_006044,NM_006312,NM_007294,NM_007297,NM_007298,NM_007299,NM_007300,NM_013261,NM_014389,NM_015001,NM_015859,NM_021059,NM_021150,NM_053056,NM_199141,NM_201595
GENE_SYMBOLS	ESR1,NR0B1,HDAC5,SRA1,NCOR2,CREBBP,ESR1,ESR1,ESR1,MEF2C,PHB2,TBP,GRIP1,MEF2C,MEF2C,MEF2C,MEF2C,NCOR2,SRA1,PHB2,EP300,HDAC2,MEF2C,TBP,NRIP1,HDAC3,CREBBP,MED1,HDAC1,HDAC5,HDAC4,HDAC6,NCOR2,BRCA1,BRCA1,BRCA1,BRCA1,BRCA1,PPARGC1A,PELP1,SPEN,GTF2A1,H3C14,GRIP1,CCND1,CARM1,GTF2A1
FOUNDER_NAMES