STANDARD_NAME	BIOCARTA_CCR3_PATHWAY
SYSTEMATIC_NAME	M9152
COLLECTION	C2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_CCR3_PATHWAY
NAMESPACE	HUMAN_SEQ_ACCESSION
DESCRIPTION_BRIEF	CCR3 signaling in Eosinophils
DESCRIPTION_FULL	Eosinophils are a key class of leukocytes involved in inflammatory responses, including allergic reactions in skin and airway. The eosinophil response in inflammation is absent in mice lacking CCR3, indicating the key role of this G protein coupled receptor in inflammation and allergic responses. Eotaxin is a chemokine ligand for CCR3 that recruits eosinophils to the site of inflammation and activates them. Other chemokine ligands of CCR3 include eotaxin-2, MCP-3, MCP-4, and RANTES. Multiple signaling pathways activated by CCR3 participate in the inflammatory response of eosinophils. Eotaxin stimulates intracellular calcium release, production of reactive oxygen species, and changes in actin polymerization through a pertussis sensitive pathway. Rho and ROCK regulate actin stress fiber formation and are required for eosinophil chemotaxis. Rho is a G protein that activates ROCK, a protein kinase. Map kinase pathways are also involved in chemotaxis. Another key action of activated eosinophils is the release of reactive oxygen species, causing tissue damage during chronic inflammatory responses. Blocking eosinophil activation and the signaling pathways that lead to chemotaxis, degranulation and reactive oxygen release may alleviate inflammatory conditions and inflammation-associated tissue damage.
PMID	
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AUTHORS	
CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_ccr3Pathway.gif
SOURCE_MEMBERS	AK055431,NM_000432,NM_000516,NM_001040056,NM_001077488,NM_001077489,NM_001077490,NM_001109891,NM_001130442,NM_001164680,NM_001167857,NM_001167858,NM_001197131,NM_001204426,NM_001664,NM_001837,NM_002072,NM_002314,NM_002481,NM_002737,NM_002738,NM_002745,NM_002746,NM_002755,NM_002880,NM_002986,NM_004570,NM_004850,NM_005343,NM_007052,NM_013955,NM_015192,NM_016592,NM_032103,NM_032104,NM_080425,NM_080426,NM_138957,NM_176795,NM_178328,NM_178329,NM_182734,NM_212535
GENE_SYMBOLS	PRKCA,MYL2,GNAS,MAPK3,GNAS,GNAS,GNAS,MAPK3,HRAS,CCR3,PPP1R12B,PPP1R12B,PPP1R12B,LIMK1,RHOA,CCR3,GNAQ,LIMK1,PPP1R12B,PRKCA,PRKCB,MAPK1,MAPK3,MAP2K1,RAF1,CCL11,PIK3C2G,ROCK2,HRAS,NOX1,NOX1,PLCB1,GNAS,PPP1R12B,PPP1R12B,GNAS,GNAS,MAPK1,HRAS,CCR3,CCR3,PLCB1,PRKCB
FOUNDER_NAMES