STANDARD_NAME	BIOCARTA_CCR5_PATHWAY
SYSTEMATIC_NAME	M2349
COLLECTION	C2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_CCR5_PATHWAY
NAMESPACE	HUMAN_SEQ_ACCESSION
DESCRIPTION_BRIEF	Pertussis toxin-insensitive CCR5 Signaling in Macrophage
DESCRIPTION_FULL	The chemokine receptors CCR5 and CXCR4 in macrophages are activated by their peptide ligands and also by the HIV envelope protein GP120 during HIV infection. One mechanism of signaling by these GPCRs is through activation of Gi signaling. These chemokine receptors can also signal through a Gi-independent pertussis toxin-insensitive pathway. This pathway elevates calcium influx into the cell through CRAC channels, ion channels that are activated by calcium release. Elevated calcium from CRAC is required for downstream activation of Pyk2, a focal adhesion-associated protein kinase. Non Gi signaling by these chemokine receptors also involves the Jnk and p38 Map kinase pathways leading to AP-1 activation and activation of genes such as MIP-1 and MCP-1. This pathway may be involved in the role of macrophages in the pathogenesis of AIDS.
PMID	
GEOID	
AUTHORS	
CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_ccr5Pathway.gif
SOURCE_MEMBERS	AK055431,BF795331,BQ218507,NM_000579,NM_000609,NM_001008540,NM_001033886,NM_001100168,NM_001178134,NM_001315,NM_001743,NM_002072,NM_002228,NM_002660,NM_002737,NM_002738,NM_002750,NM_002982,NM_002984,NM_003467,NM_004103,NM_005184,NM_005252,NM_006888,NM_139012,NM_139013,NM_139014,NM_139046,NM_139047,NM_139049,NM_173174,NM_173175,NM_173176,NM_182811,NM_199168,NM_212535
GENE_SYMBOLS	PRKCA,,CALM1,CCR5,CXCL12,CXCR4,CXCL12,CCR5,CXCL12,MAPK14,CALM2,GNAQ,JUN,PLCG1,PRKCA,PRKCB,MAPK8,CCL2,CCL4,CXCR4,PTK2B,CALM3,FOS,CALM1,MAPK14,MAPK14,MAPK14,MAPK8,,MAPK8,PTK2B,PTK2B,PTK2B,PLCG1,CXCL12,PRKCB
FOUNDER_NAMES