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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="BIOCARTA_CCR5_PATHWAY" SYSTEMATIC_NAME="M2349" HISTORICAL_NAMES="" PMID="" AUTHORS="" GEOID="" EXACT_SOURCE="" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_ccr5Pathway.gif" CHIP="HUMAN_SEQ_ACCESSION" CONTRIBUTOR="BioCarta" CONTRIBUTOR_ORG="BioCarta" DESCRIPTION_BRIEF="Pertussis toxin-insensitive CCR5 Signaling in Macrophage" DESCRIPTION_FULL="The chemokine receptors CCR5 and CXCR4 in macrophages are activated by their peptide ligands and also by the HIV envelope protein GP120 during HIV infection. One mechanism of signaling by these GPCRs is through activation of Gi signaling. These chemokine receptors can also signal through a Gi-independent pertussis toxin-insensitive pathway. This pathway elevates calcium influx into the cell through CRAC channels, ion channels that are activated by calcium release. Elevated calcium from CRAC is required for downstream activation of Pyk2, a focal adhesion-associated protein kinase. Non Gi signaling by these chemokine receptors also involves the Jnk and p38 Map kinase pathways leading to AP-1 activation and activation of genes such as MIP-1 and MCP-1. This pathway may be involved in the role of macrophages in the pathogenesis of AIDS." TAGS="" MEMBERS="AK055431,BF795331,BQ218507,NM_000579,NM_000609,NM_001008540,NM_001033886,NM_001100168,NM_001178134,NM_001315,NM_001743,NM_002072,NM_002228,NM_002660,NM_002737,NM_002738,NM_002750,NM_002982,NM_002984,NM_003467,NM_004103,NM_005184,NM_005252,NM_006888,NM_139012,NM_139013,NM_139014,NM_139046,NM_139047,NM_139049,NM_173174,NM_173175,NM_173176,NM_182811,NM_199168,NM_212535" MEMBERS_SYMBOLIZED="CALM1,CALM2,CALM3,CCL2,CCL4,CCR5,CXCL12,CXCR4,FOS,GNAQ,JUN,MAPK14,MAPK8,PLCG1,PRKCA,PRKCB,PTK2B" MEMBERS_EZID="1234,1432,2185,2353,2776,3725,5335,5578,5579,5599,6347,6351,6387,7852,801,805,808" MEMBERS_MAPPING="AK055431,PRKCA,5578|BF795331,null,null|BQ218507,CALM1,801|NM_000579,CCR5,1234|NM_000609,CXCL12,6387|NM_001008540,CXCR4,7852|NM_001033886,CXCL12,6387|NM_001100168,CCR5,1234|NM_001178134,CXCL12,6387|NM_001315,MAPK14,1432|NM_001743,CALM2,805|NM_002072,GNAQ,2776|NM_002228,JUN,3725|NM_002660,PLCG1,5335|NM_002737,PRKCA,5578|NM_002738,PRKCB,5579|NM_002750,MAPK8,5599|NM_002982,CCL2,6347|NM_002984,CCL4,6351|NM_003467,CXCR4,7852|NM_004103,PTK2B,2185|NM_005184,CALM3,808|NM_005252,FOS,2353|NM_006888,CALM1,801|NM_139012,MAPK14,1432|NM_139013,MAPK14,1432|NM_139014,MAPK14,1432|NM_139046,MAPK8,5599|NM_139047,null,null|NM_139049,MAPK8,5599|NM_173174,PTK2B,2185|NM_173175,PTK2B,2185|NM_173176,PTK2B,2185|NM_182811,PLCG1,5335|NM_199168,CXCL12,6387|NM_212535,PRKCB,5579" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CP:BIOCARTA"/>
</MSIGDB>
