STANDARD_NAME	BIOCARTA_CREB_PATHWAY
SYSTEMATIC_NAME	M9070
COLLECTION	C2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_CREB_PATHWAY
NAMESPACE	HUMAN_SEQ_ACCESSION
DESCRIPTION_BRIEF	Transcription factor CREB and its extracellular signals
DESCRIPTION_FULL	The transcription factor CREB binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Protein kinase A and the calmodulin-dependent protein kinases CaMKII stimulate CREB phosphorylation at Ser133, a key regulatory site controlling transcriptional activity. Growth and neurotrophic factors also stimulate CREB phosphorylation at Ser133. Phosphorylation occurs at Ser133 via p44/42 MAP Kinase and p90RSK and also via p38 MAP Kinase and MSK1. CREB exhibit deficiencies in spatial learning tasks, while flies overexpressing or lacking CREB show enhanced or diminished learning, respectively.
PMID	
GEOID	
AUTHORS	
CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_crebPathway.gif
SOURCE_MEMBERS	AI334281,AK021510,AK055431,AL833457,BM458681,NM_001006665,NM_001014431,NM_001014432,NM_001040056,NM_001109891,NM_001130442,NM_001164758,NM_001164759,NM_001164760,NM_001164761,NM_001164762,NM_001242466,NM_001242857,NM_001242858,NM_001242859,NM_001242860,NM_001242861,NM_001242862,NM_001315,NM_002086,NM_002731,NM_002732,NM_002734,NM_002735,NM_002736,NM_002737,NM_002738,NM_002745,NM_002746,NM_002953,NM_004157,NM_004379,NM_004755,NM_005163,NM_005343,NM_005633,NM_006218,NM_006908,NM_018890,NM_021116,NM_134442,NM_138957,NM_139012,NM_139013,NM_139014,NM_176795,NM_181504,NM_181523,NM_181524,NM_182398,NM_182948,NM_203506,NM_207578,NM_212471,NM_212472,NM_212535
GENE_SYMBOLS	PIK3R1,PIK3CA,PRKCA,SOS1,,RPS6KA1,AKT1,AKT1,MAPK3,MAPK3,HRAS,PRKAR1B,PRKAR1B,PRKAR1B,PRKAR1B,PRKAR1B,PIK3R1,PRKACB,PRKACB,PRKACB,PRKACB,PRKACB,PRKACB,MAPK14,GRB2,PRKACB,PRKACG,PRKAR1A,PRKAR1B,PRKAR2B,PRKCA,PRKCB,MAPK1,MAPK3,RPS6KA1,PRKAR2A,CREB1,RPS6KA5,AKT1,HRAS,SOS1,PIK3CA,RAC1,RAC1,ADCY1,CREB1,MAPK1,MAPK14,MAPK14,MAPK14,HRAS,PIK3R1,PIK3R1,PIK3R1,RPS6KA5,PRKACB,GRB2,PRKACB,PRKAR1A,PRKAR1A,PRKCB
FOUNDER_NAMES