STANDARD_NAME	BIOCARTA_CTCF_PATHWAY
SYSTEMATIC_NAME	M11420
COLLECTION	C2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_CTCF_PATHWAY
NAMESPACE	HUMAN_SEQ_ACCESSION
DESCRIPTION_BRIEF	CTCF: First Multivalent Nuclear Factor
DESCRIPTION_FULL	CTCF is central to signaling pathways in immature B cells elicited by cross-linking the Ig BCR and stimulation with TGF. Both stimuli result in induction of cell cycle arrest and apoptosis. BCR ligation stimulates a transient induction of MYC that leads to high level CTCF expression and feedback suppression of MYC transcription. BCR ligation also activates PTEN opposing PI3K activation of MYC. Pharmacologic inactivation of PI3K or mTOR/FRAP results in suppression of S6K resulting in activation of CTCF and suppression of MYC. CTCF activation induces transcriptional activation of p19ARF, with its downstream consequences, and of p27. Growth arrest is occasioned by co-expression of p21 and p27 and inhibition of MYC. CTCF, is bona fide multivalent DNA-sequence binder which specificity is mediated by different sets of zinc fingers (ZFs). For three different DNA target sites, particular groups of ZFs which cannot be deleted from the 11 ZF domain without loosing binding to a given site, are shown by a rainbow in the box on the left.
PMID	
GEOID	
AUTHORS	
CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_ctcfPathway.gif
SOURCE_MEMBERS	AI279872,AI334281,AK021510,BI834312,BM458681,BM469215,JX015388,NM_000077,NM_000314,NM_000546,NM_000626,NM_000660,NM_001001419,NM_001001420,NM_001003688,NM_001024847,NM_001039933,NM_001126112,NM_001126113,NM_001126114,NM_001126115,NM_001126116,NM_001126117,NM_001126118,NM_001130916,NM_001135599,NM_001191022,NM_001195132,NM_001195683,NM_001195684,NM_001242466,NM_001783,NM_002392,NM_002467,NM_002649,NM_002715,NM_003161,NM_003238,NM_003239,NM_003242,NM_003243,NM_004064,NM_004612,NM_004958,NM_005359,NM_005900,NM_005903,NM_006218,NM_006565,NM_021601,NM_021602,NM_058195,NM_058197,NM_181504,NM_181523,NM_181524
GENE_SYMBOLS	TGFBR2,PIK3R1,PIK3CA,,,TP53,MDM2,CDKN2A,PTEN,TP53,CD79B,TGFB1,SMAD5,SMAD5,SMAD1,TGFBR2,CD79B,TP53,TP53,TP53,TP53,TP53,TP53,TP53,TGFBR1,TGFB2,CTCF,CDKN2A,TGFBR3,TGFBR3,PIK3R1,CD79A,MDM2,MYC,PIK3CG,PPP2CA,RPS6KB1,TGFB2,TGFB3,TGFBR2,TGFBR3,CDKN1B,TGFBR1,MTOR,SMAD4,SMAD1,SMAD5,PIK3CA,CTCF,CD79A,CD79B,CDKN2A,CDKN2A,PIK3R1,PIK3R1,PIK3R1
FOUNDER_NAMES