STANDARD_NAME	BIOCARTA_EIF4_PATHWAY
SYSTEMATIC_NAME	M4791
COLLECTION	C2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_EIF4_PATHWAY
NAMESPACE	HUMAN_SEQ_ACCESSION
DESCRIPTION_BRIEF	Regulation of eIF4e and p70 S6 Kinase
DESCRIPTION_FULL	eIF-4F and p70 S6 kinase play critical roles in translational regulation. eIF-4F is a complex whose functions include the recognition of the mRNA 5' cap structure (eIF-4E), delivery of an RNA helicase to the 5' region (eIF-4A), bridging of the mRNA and the ribosome (eIF-4G), and circularization of the mRNA via interaction between eIF-4G and the poly(A) binding protein (PABP). Several stimuli, including growth factors and cytokines, regulate the eIF-4 complex and p70 S6 kinase by initiating a phosphorylation cascade involving the sequential activation of PI3-K, PDK1/2, Akt/PKB, and FRAP/mTOR kinase. FRAP/mTOR, together with an unidentified kinase, phosphorylates 4E-BP, leading to its dissociation from and activation of eIF-4E. MNK1/2, activated by ERK and p38 MAPK, phosphorylates and activates eIF-4E. Both processes contribute to the association of eIF-4E and eIF-4G to form the active eIF-4F complex, a necessary component of the 48S initiation complex. Phosphorylation of ribosomal protein S6 by p70 S6 kinase stimulates the translation of mRNAs with a 5' oligopyrimidine tract which typically encode components of the protein synthesis.
PMID	
GEOID	
AUTHORS	
CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_eif4Pathway.gif
SOURCE_MEMBERS	AI334281,AK021510,AK055431,BC039344,BM458681,BQ644097,HY197260,NM_000163,NM_000314,NM_001014431,NM_001014432,NM_001040056,NM_001042559,NM_001109891,NM_001130678,NM_001130679,NM_001135553,NM_001172705,NM_001194946,NM_001194947,NM_001198801,NM_001198802,NM_001198803,NM_001199898,NM_001199899,NM_001199900,NM_001204510,NM_001242399,NM_001242400,NM_001242401,NM_001242402,NM_001242403,NM_001242404,NM_001242405,NM_001242406,NM_001242460,NM_001242461,NM_001242462,NM_001242466,NM_001261816,NM_001315,NM_001416,NM_001418,NM_001967,NM_001968,NM_002568,NM_002611,NM_002613,NM_002737,NM_002738,NM_002745,NM_002746,NM_003161,NM_003684,NM_003760,NM_004095,NM_004953,NM_004958,NM_005163,NM_005544,NM_006218,NM_031268,NM_138957,NM_139012,NM_139013,NM_139014,NM_181504,NM_181523,NM_181524,NM_182917,NM_198241,NM_198242,NM_198244,NM_198973,NM_212535,Z11851
GENE_SYMBOLS	PIK3R1,PIK3CA,PRKCA,EIF4A2,,,GHR,GHR,PTEN,AKT1,AKT1,MAPK3,EIF4G2,MAPK3,EIF4E,EIF4E,MKNK1,EIF4G2,EIF4G1,EIF4G1,EIF4G3,EIF4G3,EIF4G3,PDK2,PDK2,PDK2,EIF4A1,GHR,GHR,GHR,GHR,GHR,GHR,GHR,GHR,GHR,GHR,GHR,PIK3R1,PDPK1,MAPK14,EIF4A1,EIF4G2,EIF4A2,EIF4E,PABPC1,PDK2,PDPK1,PRKCA,PRKCB,MAPK1,MAPK3,RPS6KB1,MKNK1,EIF4G3,EIF4EBP1,EIF4G1,MTOR,AKT1,IRS1,PIK3CA,PDPK1,MAPK1,MAPK14,MAPK14,MAPK14,PIK3R1,PIK3R1,PIK3R1,EIF4G1,EIF4G1,EIF4G1,EIF4G1,MKNK1,PRKCB,GHR
FOUNDER_NAMES