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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="BIOCARTA_EIF4_PATHWAY" SYSTEMATIC_NAME="M4791" HISTORICAL_NAMES="" PMID="" AUTHORS="" GEOID="" EXACT_SOURCE="" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_eif4Pathway.gif" CHIP="HUMAN_SEQ_ACCESSION" CONTRIBUTOR="BioCarta" CONTRIBUTOR_ORG="BioCarta" DESCRIPTION_BRIEF="Regulation of eIF4e and p70 S6 Kinase" DESCRIPTION_FULL="eIF-4F and p70 S6 kinase play critical roles in translational regulation. eIF-4F is a complex whose functions include the recognition of the mRNA 5' cap structure (eIF-4E), delivery of an RNA helicase to the 5' region (eIF-4A), bridging of the mRNA and the ribosome (eIF-4G), and circularization of the mRNA via interaction between eIF-4G and the poly(A) binding protein (PABP). Several stimuli, including growth factors and cytokines, regulate the eIF-4 complex and p70 S6 kinase by initiating a phosphorylation cascade involving the sequential activation of PI3-K, PDK1/2, Akt/PKB, and FRAP/mTOR kinase. FRAP/mTOR, together with an unidentified kinase, phosphorylates 4E-BP, leading to its dissociation from and activation of eIF-4E. MNK1/2, activated by ERK and p38 MAPK, phosphorylates and activates eIF-4E. Both processes contribute to the association of eIF-4E and eIF-4G to form the active eIF-4F complex, a necessary component of the 48S initiation complex. Phosphorylation of ribosomal protein S6 by p70 S6 kinase stimulates the translation of mRNAs with a 5' oligopyrimidine tract which typically encode components of the protein synthesis." TAGS="" MEMBERS="AI334281,AK021510,AK055431,BC039344,BM458681,BQ644097,HY197260,NM_000163,NM_000314,NM_001014431,NM_001014432,NM_001040056,NM_001042559,NM_001109891,NM_001130678,NM_001130679,NM_001135553,NM_001172705,NM_001194946,NM_001194947,NM_001198801,NM_001198802,NM_001198803,NM_001199898,NM_001199899,NM_001199900,NM_001204510,NM_001242399,NM_001242400,NM_001242401,NM_001242402,NM_001242403,NM_001242404,NM_001242405,NM_001242406,NM_001242460,NM_001242461,NM_001242462,NM_001242466,NM_001261816,NM_001315,NM_001416,NM_001418,NM_001967,NM_001968,NM_002568,NM_002611,NM_002613,NM_002737,NM_002738,NM_002745,NM_002746,NM_003161,NM_003684,NM_003760,NM_004095,NM_004953,NM_004958,NM_005163,NM_005544,NM_006218,NM_031268,NM_138957,NM_139012,NM_139013,NM_139014,NM_181504,NM_181523,NM_181524,NM_182917,NM_198241,NM_198242,NM_198244,NM_198973,NM_212535,Z11851" MEMBERS_SYMBOLIZED="AKT1,EIF4A1,EIF4A2,EIF4E,EIF4EBP1,EIF4G1,EIF4G2,EIF4G3,GHR,IRS1,MAPK1,MAPK14,MAPK3,MKNK1,MTOR,PABPC1,PDK2,PDPK1,PIK3CA,PIK3R1,PRKCA,PRKCB,PTEN,RPS6KB1" MEMBERS_EZID="1432,1973,1974,1977,1978,1981,1982,207,2475,2690,26986,3667,5164,5170,5290,5295,5578,5579,5594,5595,5728,6198,8569,8672" MEMBERS_MAPPING="AI334281,PIK3R1,5295|AK021510,PIK3CA,5290|AK055431,PRKCA,5578|BC039344,EIF4A2,1974|BM458681,null,null|BQ644097,null,null|HY197260,GHR,2690|NM_000163,GHR,2690|NM_000314,PTEN,5728|NM_001014431,AKT1,207|NM_001014432,AKT1,207|NM_001040056,MAPK3,5595|NM_001042559,EIF4G2,1982|NM_001109891,MAPK3,5595|NM_001130678,EIF4E,1977|NM_001130679,EIF4E,1977|NM_001135553,MKNK1,8569|NM_001172705,EIF4G2,1982|NM_001194946,EIF4G1,1981|NM_001194947,EIF4G1,1981|NM_001198801,EIF4G3,8672|NM_001198802,EIF4G3,8672|NM_001198803,EIF4G3,8672|NM_001199898,PDK2,5164|NM_001199899,PDK2,5164|NM_001199900,PDK2,5164|NM_001204510,EIF4A1,1973|NM_001242399,GHR,2690|NM_001242400,GHR,2690|NM_001242401,GHR,2690|NM_001242402,GHR,2690|NM_001242403,GHR,2690|NM_001242404,GHR,2690|NM_001242405,GHR,2690|NM_001242406,GHR,2690|NM_001242460,GHR,2690|NM_001242461,GHR,2690|NM_001242462,GHR,2690|NM_001242466,PIK3R1,5295|NM_001261816,PDPK1,5170|NM_001315,MAPK14,1432|NM_001416,EIF4A1,1973|NM_001418,EIF4G2,1982|NM_001967,EIF4A2,1974|NM_001968,EIF4E,1977|NM_002568,PABPC1,26986|NM_002611,PDK2,5164|NM_002613,PDPK1,5170|NM_002737,PRKCA,5578|NM_002738,PRKCB,5579|NM_002745,MAPK1,5594|NM_002746,MAPK3,5595|NM_003161,RPS6KB1,6198|NM_003684,MKNK1,8569|NM_003760,EIF4G3,8672|NM_004095,EIF4EBP1,1978|NM_004953,EIF4G1,1981|NM_004958,MTOR,2475|NM_005163,AKT1,207|NM_005544,IRS1,3667|NM_006218,PIK3CA,5290|NM_031268,PDPK1,5170|NM_138957,MAPK1,5594|NM_139012,MAPK14,1432|NM_139013,MAPK14,1432|NM_139014,MAPK14,1432|NM_181504,PIK3R1,5295|NM_181523,PIK3R1,5295|NM_181524,PIK3R1,5295|NM_182917,EIF4G1,1981|NM_198241,EIF4G1,1981|NM_198242,EIF4G1,1981|NM_198244,EIF4G1,1981|NM_198973,MKNK1,8569|NM_212535,PRKCB,5579|Z11851,GHR,2690" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CP:BIOCARTA"/>
</MSIGDB>
