<?xml version="1.0" encoding="UTF-8" standalone="yes"?>

<!-- Copyright (c) 2004-2026 Broad Institute, Inc., Massachusetts Institute of Technology, and Regents of the University of California.  All rights reserved.
     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
-->
<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="BIOCARTA_EPO_PATHWAY" SYSTEMATIC_NAME="M12836" HISTORICAL_NAMES="" PMID="" AUTHORS="" GEOID="" EXACT_SOURCE="" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_epoPathway.gif" CHIP="HUMAN_SEQ_ACCESSION" CONTRIBUTOR="BioCarta" CONTRIBUTOR_ORG="BioCarta" DESCRIPTION_BRIEF="EPO Signaling Pathway" DESCRIPTION_FULL="Erythropoietin functions to increase the number of red blood cells. Thus, it has found utility as a drug for those needing to replenish erythrocytes for a number of reasons. The signaling mechanism includes multimerization of the receptor upon ligand binding, activation of MAPK cascade, and phosphorylation and activation of Stat5." TAGS="" MEMBERS="AL833457,BG682876,BQ877285,NM_000121,NM_000799,NM_001040056,NM_001109891,NM_001114123,NM_001130040,NM_001130041,NM_001130442,NM_001202859,NM_001257168,NM_001895,NM_002086,NM_002228,NM_002660,NM_002746,NM_002750,NM_002755,NM_002831,NM_002880,NM_003029,NM_003152,NM_004972,NM_005229,NM_005252,NM_005343,NM_005633,NM_012448,NM_080548,NM_080549,NM_139046,NM_139047,NM_139049,NM_176795,NM_177559,NM_177560,NM_182811,NM_183001,NM_203506" MEMBERS_SYMBOLIZED="CSNK2A1,ELK1,EPO,EPOR,FOS,GRB2,HRAS,JAK2,JUN,MAP2K1,MAPK3,MAPK8,PLCG1,PTPN6,RAF1,SHC1,SOS1,STAT5A,STAT5B" MEMBERS_EZID="1457,2002,2056,2057,2353,2885,3265,3717,3725,5335,5595,5599,5604,5777,5894,6464,6654,6776,6777" MEMBERS_MAPPING="AL833457,SOS1,6654|BG682876,null,null|BQ877285,null,null|NM_000121,EPOR,2057|NM_000799,EPO,2056|NM_001040056,MAPK3,5595|NM_001109891,MAPK3,5595|NM_001114123,ELK1,2002|NM_001130040,SHC1,6464|NM_001130041,SHC1,6464|NM_001130442,HRAS,3265|NM_001202859,SHC1,6464|NM_001257168,ELK1,2002|NM_001895,CSNK2A1,1457|NM_002086,GRB2,2885|NM_002228,JUN,3725|NM_002660,PLCG1,5335|NM_002746,MAPK3,5595|NM_002750,MAPK8,5599|NM_002755,MAP2K1,5604|NM_002831,PTPN6,5777|NM_002880,RAF1,5894|NM_003029,SHC1,6464|NM_003152,STAT5A,6776|NM_004972,JAK2,3717|NM_005229,ELK1,2002|NM_005252,FOS,2353|NM_005343,HRAS,3265|NM_005633,SOS1,6654|NM_012448,STAT5B,6777|NM_080548,PTPN6,5777|NM_080549,PTPN6,5777|NM_139046,MAPK8,5599|NM_139047,null,null|NM_139049,MAPK8,5599|NM_176795,HRAS,3265|NM_177559,CSNK2A1,1457|NM_177560,CSNK2A1,1457|NM_182811,PLCG1,5335|NM_183001,SHC1,6464|NM_203506,GRB2,2885" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CP:BIOCARTA"/>
</MSIGDB>
