STANDARD_NAME	BIOCARTA_GATA3_PATHWAY
SYSTEMATIC_NAME	M1394
COLLECTION	C2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_GATA3_PATHWAY
NAMESPACE	HUMAN_SEQ_ACCESSION
DESCRIPTION_BRIEF	GATA3 participate in activating the Th2 cytokine genes expression
DESCRIPTION_FULL	CD4+ helper T cells differentiate into distinct subtypes, Th1 and Th2 cells. Th2 cells are involved in the response to extracellular helminthe parasites and allergic responses and secrete a distinct set of cytokines including IL-4, IL-5 and IL-13. The development and differentiation of T cells is influenced by many factors, including transcription factors such as GATA-3, a transcription factor associated with induction of Th2 cells. Factors that increase cAMP levels in Th2 cells activate p38 kinase, which phosphorylates and activates GATA-3 independently of PKA. Cells expressing GATA-3 develop the profile of Th2 cells, secreting IL-4, IL-5 and IL-13. These cytokines are found in a gene cluster together and are regulated coordinately by GATA-3. Binding of GATA-3 in the regulatory regions of these genes alters chromatin structure, increasing accessibility to other transcription factors. Activation of the T cell receptor through interaction with antigen on antigen presenting cells activates NFAT and other transcription factors that cooperate with GATA-3 in inducing Th2 cell differentiation. Dominant negative GATA-3 can repress the secretion of these cytokines and block the airway inflammation that causes asthma. Blocking GATA-3 action such as through antisense treatment has been suggested as a therapeutic strategy to treat asthma. GATA-3 has also been implicated in developmental processes such as the development of the inner ear.
PMID	
GEOID	
AUTHORS	
CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_gata3Pathway.gif
SOURCE_MEMBERS	BC045628,NM_000589,NM_000879,NM_001002295,NM_001136021,NM_001164758,NM_001164759,NM_001164760,NM_001164761,NM_001164762,NM_001242857,NM_001242858,NM_001242859,NM_001242860,NM_001242861,NM_001242862,NM_001258292,NM_001258294,NM_001258295,NM_001258296,NM_001258297,NM_001315,NM_002051,NM_002188,NM_002731,NM_002732,NM_002734,NM_002735,NM_002736,NM_002756,NM_004157,NM_006162,NM_012340,NM_139012,NM_139013,NM_139014,NM_145109,NM_172348,NM_172387,NM_172388,NM_172389,NM_172390,NM_173091,NM_182948,NM_207578,NM_212471,NM_212472
GENE_SYMBOLS	NFATC1,IL4,IL5,GATA3,NFATC2,PRKAR1B,PRKAR1B,PRKAR1B,PRKAR1B,PRKAR1B,PRKACB,PRKACB,PRKACB,PRKACB,PRKACB,PRKACB,NFATC2,NFATC2,NFATC2,NFATC2,NFATC2,MAPK14,GATA3,IL13,PRKACB,PRKACG,PRKAR1A,PRKAR1B,PRKAR2B,MAP2K3,PRKAR2A,NFATC1,NFATC2,MAPK14,MAPK14,MAPK14,MAP2K3,IL4,NFATC1,NFATC1,NFATC1,NFATC1,NFATC2,PRKACB,PRKACB,PRKAR1A,PRKAR1A
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