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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="BIOCARTA_GATA3_PATHWAY" SYSTEMATIC_NAME="M1394" HISTORICAL_NAMES="" PMID="" AUTHORS="" GEOID="" EXACT_SOURCE="" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_gata3Pathway.gif" CHIP="HUMAN_SEQ_ACCESSION" CONTRIBUTOR="BioCarta" CONTRIBUTOR_ORG="BioCarta" DESCRIPTION_BRIEF="GATA3 participate in activating the Th2 cytokine genes expression" DESCRIPTION_FULL="CD4+ helper T cells differentiate into distinct subtypes, Th1 and Th2 cells. Th2 cells are involved in the response to extracellular helminthe parasites and allergic responses and secrete a distinct set of cytokines including IL-4, IL-5 and IL-13. The development and differentiation of T cells is influenced by many factors, including transcription factors such as GATA-3, a transcription factor associated with induction of Th2 cells. Factors that increase cAMP levels in Th2 cells activate p38 kinase, which phosphorylates and activates GATA-3 independently of PKA. Cells expressing GATA-3 develop the profile of Th2 cells, secreting IL-4, IL-5 and IL-13. These cytokines are found in a gene cluster together and are regulated coordinately by GATA-3. Binding of GATA-3 in the regulatory regions of these genes alters chromatin structure, increasing accessibility to other transcription factors. Activation of the T cell receptor through interaction with antigen on antigen presenting cells activates NFAT and other transcription factors that cooperate with GATA-3 in inducing Th2 cell differentiation. Dominant negative GATA-3 can repress the secretion of these cytokines and block the airway inflammation that causes asthma. Blocking GATA-3 action such as through antisense treatment has been suggested as a therapeutic strategy to treat asthma. GATA-3 has also been implicated in developmental processes such as the development of the inner ear." TAGS="" MEMBERS="BC045628,NM_000589,NM_000879,NM_001002295,NM_001136021,NM_001164758,NM_001164759,NM_001164760,NM_001164761,NM_001164762,NM_001242857,NM_001242858,NM_001242859,NM_001242860,NM_001242861,NM_001242862,NM_001258292,NM_001258294,NM_001258295,NM_001258296,NM_001258297,NM_001315,NM_002051,NM_002188,NM_002731,NM_002732,NM_002734,NM_002735,NM_002736,NM_002756,NM_004157,NM_006162,NM_012340,NM_139012,NM_139013,NM_139014,NM_145109,NM_172348,NM_172387,NM_172388,NM_172389,NM_172390,NM_173091,NM_182948,NM_207578,NM_212471,NM_212472" MEMBERS_SYMBOLIZED="GATA3,IL13,IL4,IL5,MAP2K3,MAPK14,NFATC1,NFATC2,PRKACB,PRKACG,PRKAR1A,PRKAR1B,PRKAR2A,PRKAR2B" MEMBERS_EZID="1432,2625,3565,3567,3596,4772,4773,5567,5568,5573,5575,5576,5577,5606" MEMBERS_MAPPING="BC045628,NFATC1,4772|NM_000589,IL4,3565|NM_000879,IL5,3567|NM_001002295,GATA3,2625|NM_001136021,NFATC2,4773|NM_001164758,PRKAR1B,5575|NM_001164759,PRKAR1B,5575|NM_001164760,PRKAR1B,5575|NM_001164761,PRKAR1B,5575|NM_001164762,PRKAR1B,5575|NM_001242857,PRKACB,5567|NM_001242858,PRKACB,5567|NM_001242859,PRKACB,5567|NM_001242860,PRKACB,5567|NM_001242861,PRKACB,5567|NM_001242862,PRKACB,5567|NM_001258292,NFATC2,4773|NM_001258294,NFATC2,4773|NM_001258295,NFATC2,4773|NM_001258296,NFATC2,4773|NM_001258297,NFATC2,4773|NM_001315,MAPK14,1432|NM_002051,GATA3,2625|NM_002188,IL13,3596|NM_002731,PRKACB,5567|NM_002732,PRKACG,5568|NM_002734,PRKAR1A,5573|NM_002735,PRKAR1B,5575|NM_002736,PRKAR2B,5577|NM_002756,MAP2K3,5606|NM_004157,PRKAR2A,5576|NM_006162,NFATC1,4772|NM_012340,NFATC2,4773|NM_139012,MAPK14,1432|NM_139013,MAPK14,1432|NM_139014,MAPK14,1432|NM_145109,MAP2K3,5606|NM_172348,IL4,3565|NM_172387,NFATC1,4772|NM_172388,NFATC1,4772|NM_172389,NFATC1,4772|NM_172390,NFATC1,4772|NM_173091,NFATC2,4773|NM_182948,PRKACB,5567|NM_207578,PRKACB,5567|NM_212471,PRKAR1A,5573|NM_212472,PRKAR1A,5573" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CP:BIOCARTA"/>
</MSIGDB>
