STANDARD_NAME	BIOCARTA_GPCR_PATHWAY
SYSTEMATIC_NAME	M9664
COLLECTION	C2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_GPCR_PATHWAY
NAMESPACE	HUMAN_SEQ_ACCESSION
DESCRIPTION_BRIEF	Signaling Pathway from G-Protein Families
DESCRIPTION_FULL	G-aS-coupled receptors stimulate adenylyl cyclase (AC), which synthesizes cAMP from ATP. In contrast Gai-coupled receptors inhibit AC and so reduce cAMP formation. The bg subunits from Gai and other G proteins are able to activate the MAP kinase pathways and PLCb. GPCRs coupled to the Gaq family of G proteins stimulate PLCb, which cleaves membrane phospholipids to produce IP3, which mobilizes intracellular calcium, and DAG, which activates PKC. Second messenger pathways then activate a range of effector systems to change cell behaviour; in many cases this includes the regulation of gene transcription. Dotted line shows a more indirect pathway.
PMID	
GEOID	
AUTHORS	
CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_gpcrPathway.gif
SOURCE_MEMBERS	AK055431,BC045628,BG682876,BQ218507,BQ877285,NM_000944,NM_001040056,NM_001109891,NM_001114123,NM_001130442,NM_001130691,NM_001130692,NM_001136021,NM_001136022,NM_001142353,NM_001142354,NM_001164758,NM_001164759,NM_001164760,NM_001164761,NM_001164762,NM_001198965,NM_001198966,NM_001198967,NM_001242857,NM_001242858,NM_001242859,NM_001242860,NM_001242861,NM_001242862,NM_001243974,NM_001243975,NM_001257168,NM_001258292,NM_001258294,NM_001258295,NM_001258296,NM_001258297,NM_001743,NM_002072,NM_002228,NM_002660,NM_002731,NM_002732,NM_002734,NM_002735,NM_002736,NM_002737,NM_002738,NM_002746,NM_002755,NM_002880,NM_004157,NM_004379,NM_004554,NM_004555,NM_004586,NM_005184,NM_005229,NM_005252,NM_005343,NM_005605,NM_006162,NM_006888,NM_012340,NM_021116,NM_021132,NM_134442,NM_172387,NM_172388,NM_172389,NM_172390,NM_173091,NM_173163,NM_173165,NM_176795,NM_182811,NM_182948,NM_207578,NM_212471,NM_212472,NM_212535
GENE_SYMBOLS	PRKCA,NFATC1,,CALM1,,PPP3CA,MAPK3,MAPK3,ELK1,HRAS,PPP3CA,PPP3CA,NFATC2,NFATC4,PPP3CB,PPP3CB,PRKAR1B,PRKAR1B,PRKAR1B,PRKAR1B,PRKAR1B,NFATC4,NFATC4,NFATC4,PRKACB,PRKACB,PRKACB,PRKACB,PRKACB,PRKACB,PPP3CC,PPP3CC,ELK1,NFATC2,NFATC2,NFATC2,NFATC2,NFATC2,CALM2,GNAQ,JUN,PLCG1,PRKACB,PRKACG,PRKAR1A,PRKAR1B,PRKAR2B,PRKCA,PRKCB,MAPK3,MAP2K1,RAF1,PRKAR2A,CREB1,NFATC4,NFATC3,RPS6KA3,CALM3,ELK1,FOS,HRAS,PPP3CC,NFATC1,CALM1,NFATC2,ADCY1,PPP3CB,CREB1,NFATC1,NFATC1,NFATC1,NFATC1,NFATC2,NFATC3,NFATC3,HRAS,PLCG1,PRKACB,PRKACB,PRKAR1A,PRKAR1A,PRKCB
FOUNDER_NAMES