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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="BIOCARTA_GPCR_PATHWAY" SYSTEMATIC_NAME="M9664" HISTORICAL_NAMES="" PMID="" AUTHORS="" GEOID="" EXACT_SOURCE="" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_gpcrPathway.gif" CHIP="HUMAN_SEQ_ACCESSION" CONTRIBUTOR="BioCarta" CONTRIBUTOR_ORG="BioCarta" DESCRIPTION_BRIEF="Signaling Pathway from G-Protein Families" DESCRIPTION_FULL="G-aS-coupled receptors stimulate adenylyl cyclase (AC), which synthesizes cAMP from ATP. In contrast Gai-coupled receptors inhibit AC and so reduce cAMP formation. The bg subunits from Gai and other G proteins are able to activate the MAP kinase pathways and PLCb. GPCRs coupled to the Gaq family of G proteins stimulate PLCb, which cleaves membrane phospholipids to produce IP3, which mobilizes intracellular calcium, and DAG, which activates PKC. Second messenger pathways then activate a range of effector systems to change cell behaviour; in many cases this includes the regulation of gene transcription. Dotted line shows a more indirect pathway." TAGS="" MEMBERS="AK055431,BC045628,BG682876,BQ218507,BQ877285,NM_000944,NM_001040056,NM_001109891,NM_001114123,NM_001130442,NM_001130691,NM_001130692,NM_001136021,NM_001136022,NM_001142353,NM_001142354,NM_001164758,NM_001164759,NM_001164760,NM_001164761,NM_001164762,NM_001198965,NM_001198966,NM_001198967,NM_001242857,NM_001242858,NM_001242859,NM_001242860,NM_001242861,NM_001242862,NM_001243974,NM_001243975,NM_001257168,NM_001258292,NM_001258294,NM_001258295,NM_001258296,NM_001258297,NM_001743,NM_002072,NM_002228,NM_002660,NM_002731,NM_002732,NM_002734,NM_002735,NM_002736,NM_002737,NM_002738,NM_002746,NM_002755,NM_002880,NM_004157,NM_004379,NM_004554,NM_004555,NM_004586,NM_005184,NM_005229,NM_005252,NM_005343,NM_005605,NM_006162,NM_006888,NM_012340,NM_021116,NM_021132,NM_134442,NM_172387,NM_172388,NM_172389,NM_172390,NM_173091,NM_173163,NM_173165,NM_176795,NM_182811,NM_182948,NM_207578,NM_212471,NM_212472,NM_212535" MEMBERS_SYMBOLIZED="ADCY1,CALM1,CALM2,CALM3,CREB1,ELK1,FOS,GNAQ,HRAS,JUN,MAP2K1,MAPK3,NFATC1,NFATC2,NFATC3,NFATC4,PLCG1,PPP3CA,PPP3CB,PPP3CC,PRKACB,PRKACG,PRKAR1A,PRKAR1B,PRKAR2A,PRKAR2B,PRKCA,PRKCB,RAF1,RPS6KA3" MEMBERS_EZID="107,1385,2002,2353,2776,3265,3725,4772,4773,4775,4776,5335,5530,5532,5533,5567,5568,5573,5575,5576,5577,5578,5579,5595,5604,5894,6197,801,805,808" MEMBERS_MAPPING="AK055431,PRKCA,5578|BC045628,NFATC1,4772|BG682876,null,null|BQ218507,CALM1,801|BQ877285,null,null|NM_000944,PPP3CA,5530|NM_001040056,MAPK3,5595|NM_001109891,MAPK3,5595|NM_001114123,ELK1,2002|NM_001130442,HRAS,3265|NM_001130691,PPP3CA,5530|NM_001130692,PPP3CA,5530|NM_001136021,NFATC2,4773|NM_001136022,NFATC4,4776|NM_001142353,PPP3CB,5532|NM_001142354,PPP3CB,5532|NM_001164758,PRKAR1B,5575|NM_001164759,PRKAR1B,5575|NM_001164760,PRKAR1B,5575|NM_001164761,PRKAR1B,5575|NM_001164762,PRKAR1B,5575|NM_001198965,NFATC4,4776|NM_001198966,NFATC4,4776|NM_001198967,NFATC4,4776|NM_001242857,PRKACB,5567|NM_001242858,PRKACB,5567|NM_001242859,PRKACB,5567|NM_001242860,PRKACB,5567|NM_001242861,PRKACB,5567|NM_001242862,PRKACB,5567|NM_001243974,PPP3CC,5533|NM_001243975,PPP3CC,5533|NM_001257168,ELK1,2002|NM_001258292,NFATC2,4773|NM_001258294,NFATC2,4773|NM_001258295,NFATC2,4773|NM_001258296,NFATC2,4773|NM_001258297,NFATC2,4773|NM_001743,CALM2,805|NM_002072,GNAQ,2776|NM_002228,JUN,3725|NM_002660,PLCG1,5335|NM_002731,PRKACB,5567|NM_002732,PRKACG,5568|NM_002734,PRKAR1A,5573|NM_002735,PRKAR1B,5575|NM_002736,PRKAR2B,5577|NM_002737,PRKCA,5578|NM_002738,PRKCB,5579|NM_002746,MAPK3,5595|NM_002755,MAP2K1,5604|NM_002880,RAF1,5894|NM_004157,PRKAR2A,5576|NM_004379,CREB1,1385|NM_004554,NFATC4,4776|NM_004555,NFATC3,4775|NM_004586,RPS6KA3,6197|NM_005184,CALM3,808|NM_005229,ELK1,2002|NM_005252,FOS,2353|NM_005343,HRAS,3265|NM_005605,PPP3CC,5533|NM_006162,NFATC1,4772|NM_006888,CALM1,801|NM_012340,NFATC2,4773|NM_021116,ADCY1,107|NM_021132,PPP3CB,5532|NM_134442,CREB1,1385|NM_172387,NFATC1,4772|NM_172388,NFATC1,4772|NM_172389,NFATC1,4772|NM_172390,NFATC1,4772|NM_173091,NFATC2,4773|NM_173163,NFATC3,4775|NM_173165,NFATC3,4775|NM_176795,HRAS,3265|NM_182811,PLCG1,5335|NM_182948,PRKACB,5567|NM_207578,PRKACB,5567|NM_212471,PRKAR1A,5573|NM_212472,PRKAR1A,5573|NM_212535,PRKCB,5579" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CP:BIOCARTA"/>
</MSIGDB>
