STANDARD_NAME	BIOCARTA_GSK3_PATHWAY
SYSTEMATIC_NAME	M11106
COLLECTION	C2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_GSK3_PATHWAY
NAMESPACE	HUMAN_SEQ_ACCESSION
DESCRIPTION_BRIEF	Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages
DESCRIPTION_FULL	Lipopolysaccharide. One of the key actions of AKT is to block apoptosis. AKT phosphorylation of NF-kB promotes the survival and activation of macrophages responding to LPS. Another substrate of AKT is the protein kinase Gsk3-beta. AKT phosphorylates and deactivates Gsk3-beta. Non-phosphorylated Gsk3-beta is active and phosphorylates beta-catenin, leading to its degradation in the ubiquitin dependent proteosome pathway. Stimulation by LPS causes the accumulation of beta-catenin in the nucleus and the activation of genes in concert with the transcription factor LEF1. This pathway is probably not restricted to alveolar pathway, but leads to the activation of beta-catenin dependent genes by LPS in other cells as well. Other pathways regulate this pathway also, such as the modulation of PI3 kinase activity by ceramide, and the inhibition of Gsk3-beta activity by the Wnt/frizzled/disheveled (DSH) pathway.
PMID	
GEOID	
AUTHORS	
CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/H_gsk3Pathway.gif
SOURCE_MEMBERS	AI334281,AK021510,BM458681,NM_000038,NM_000165,NM_001014431,NM_001014432,NM_001098209,NM_001098210,NM_001127510,NM_001127511,NM_001130713,NM_001130714,NM_001135651,NM_001135652,NM_001145138,NM_001146156,NM_001165412,NM_001166119,NM_001172566,NM_001172567,NM_001172568,NM_001172569,NM_001242466,NM_001243984,NM_001243985,NM_001261816,NM_001904,NM_002093,NM_002468,NM_002613,NM_002715,NM_002759,NM_003502,NM_003505,NM_003998,NM_004139,NM_004421,NM_005163,NM_005430,NM_006218,NM_016269,NM_021975,NM_031268,NM_053056,NM_181050,NM_181504,NM_181523,NM_181524
GENE_SYMBOLS	PIK3R1,PIK3CA,,APC,GJA1,AKT1,AKT1,CTNNB1,CTNNB1,APC,APC,LEF1,LEF1,EIF2AK2,EIF2AK2,RELA,GSK3B,NFKB1,LEF1,MYD88,MYD88,MYD88,MYD88,PIK3R1,RELA,RELA,PDPK1,CTNNB1,GSK3B,MYD88,PDPK1,PPP2CA,EIF2AK2,AXIN1,FZD1,NFKB1,LBP,DVL1,AKT1,WNT1,PIK3CA,LEF1,RELA,PDPK1,CCND1,AXIN1,PIK3R1,PIK3R1,PIK3R1
FOUNDER_NAMES