STANDARD_NAME BIOCARTA_IGF1_PATHWAY SYSTEMATIC_NAME M2623 COLLECTION C2:CP:BIOCARTA MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_IGF1_PATHWAY NAMESPACE HUMAN_SEQ_ACCESSION DESCRIPTION_BRIEF IGF-1 Signaling Pathway DESCRIPTION_FULL Insulin like growth factor 1 (IGF-1) and its receptor (IGF-1R) provide a potent proliferative signaling system that stimulates growth in many different cell types and blocks apoptosis. In vivo IGF-1 acts as an intermediate of many growth hormone responses, and may stimulate the growth of some types of cancer. IGF-1 also provides a mitogenic signal to act as a growth factor for many tissue culture cells. One component of IGF-1 mitogenic signaling is association of the receptor tyrosine kinase with Shc, Grb2, and Sos-1 to activate ras and the Map kinase cascade (raf, Mek, Erk). An endpoint of the Map kinase pathway is modification of transcription factor activity, such as activation of ELK transcription factors. Serum response factor (SRF) and AP-1 contribute to mitogenic signaling by many factors. Phosphorylation of IRS-1 and PI3 kinase activation are also involved in IGF-1 signaling, similar to insulin signaling. PMID GEOID AUTHORS CONTRIBUTOR BioCarta CONTRIBUTOR_ORG BioCarta EXACT_SOURCE FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_igf1Pathway.gif SOURCE_MEMBERS AI334281,AK021510,AL833457,BC111788,BG682876,BM458681,BQ877285,CK300639,NM_000618,NM_000875,NM_001040056,NM_001109891,NM_001111283,NM_001111284,NM_001111285,NM_001114123,NM_001130040,NM_001130041,NM_001130442,NM_001202859,NM_001242466,NM_001257168,NM_001895,NM_002086,NM_002228,NM_002649,NM_002746,NM_002750,NM_002755,NM_002834,NM_002880,NM_002890,NM_003029,NM_003131,NM_005229,NM_005252,NM_005343,NM_005544,NM_005633,NM_006218,NM_022650,NM_080601,NM_139046,NM_139047,NM_139049,NM_176795,NM_177559,NM_177560,NM_181504,NM_181523,NM_181524,NM_183001,NM_203506 GENE_SYMBOLS PIK3R1,PIK3CA,SOS1,,,,,,IGF1,IGF1R,MAPK3,MAPK3,IGF1,IGF1,IGF1,ELK1,SHC1,SHC1,HRAS,SHC1,PIK3R1,ELK1,CSNK2A1,GRB2,JUN,PIK3CG,MAPK3,MAPK8,MAP2K1,PTPN11,RAF1,RASA1,SHC1,SRF,ELK1,FOS,HRAS,IRS1,SOS1,PIK3CA,RASA1,PTPN11,MAPK8,,MAPK8,HRAS,CSNK2A1,CSNK2A1,PIK3R1,PIK3R1,PIK3R1,SHC1,GRB2 FOUNDER_NAMES