STANDARD_NAME	BIOCARTA_IL17_PATHWAY
SYSTEMATIC_NAME	M19422
COLLECTION	C2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_IL17_PATHWAY
NAMESPACE	Human_RefSeq
DESCRIPTION_BRIEF	IL 17 Signaling Pathway
DESCRIPTION_FULL	Inflammation is a complex response involving many different cells and signaling molecules, including the secretion of the cytokine IL-17 by activated T cells. IL-17 secretion is restricted to specific subsets of T cells but the receptor for IL-17 is widely expressed throughout the body, including fibroblasts and epithelial cells. Inflammatory responses involving IL-17 probably contribute to arthritis, asthma, skin immune reactions and autoimmune disorders. Fibroblasts and other cells stimulated by IL-17 are induced themselves to secrete inflammatory and hematopoietic cytokines, including IL-6, IL-8, G-CSF and Stem Cell Factor (SCF). These cytokines in turn provoke a range of activities, including the stimulation of neutrophil proliferation and differentiation.
PMID	
GEOID	
AUTHORS	
CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_il17Pathway.gif
SOURCE_MEMBERS	NM_000073,NM_000584,NM_000588,NM_000600,NM_000616,NM_000732,NM_000733,NM_000734,NM_000759,NM_000899,NM_001025109,NM_001040651,NM_001144822,NM_001145873,NM_001178147,NM_001195014,NM_001195015,NM_001195016,NM_001195017,NM_001767,NM_001768,NM_001773,NM_001779,NM_002190,NM_003994,NM_171827,NM_172219,NM_172220,NM_198053
GENE_SYMBOLS	CD3G,CXCL8,IL3,IL6,CD4,CD3D,CD3E,CD247,CSF3,KITLG,CD34,CD3D,CD58,CD8A,CSF3,CD4,CD4,CD4,CD4,CD2,CD8A,CD34,CD58,IL17A,KITLG,CD8A,CSF3,CSF3,CD247
FOUNDER_NAMES