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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="BIOCARTA_IL1R_PATHWAY" SYSTEMATIC_NAME="M12095" HISTORICAL_NAMES="" PMID="" AUTHORS="" GEOID="" EXACT_SOURCE="" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_il1rPathway.gif" CHIP="Human_RefSeq" CONTRIBUTOR="BioCarta" CONTRIBUTOR_ORG="BioCarta" DESCRIPTION_BRIEF="Signal transduction through IL1R" DESCRIPTION_FULL="Interleukin-1 (IL-1) is a pro-inflammatory cytokine that signals primarily through the type 1 IL-1 receptor (IL-1R1). The activities of IL-1 include induction of fever, expression of vascular adhesion molecules, and roles in arthritis and septic shock. The inflammatory activities of IL-1 are partially derived by transcriptionally inducing expression of cytokines such as TNF-alpha and interferons, as well as inducing the expression of other inflammation-related genes. There are two forms of IL-1 encoded by distinct genes, IL-1 alpha and IL-1 beta. IL-1 beta is produced as a 269 amino acid precursor that is cleaved by IL-1beta converting enzyme (ICE) to the active IL-1 beta form that is secreted. IL-1 signaling is opposed by the naturally occurring peptide IL-1 receptor antagonist which is a therapeutic agent for the treatment of arthritis. The type 1 IL-1 receptor protein binds IL-1 beta but requires the IL-1 receptor accessory protein (IL-1RAcP) to transduce a signal. IL-1 binding causes activation of two kinases, IRAK-1 and IRAK-2, associated with the IL-1 receptor complex. IRAK-1 (IL-1 Receptor Associated Kinase) activates and recruits TRAF6 to the IL-1 receptor complex. TRAF6 activates two pathways, one leading to NF-kB activation and another leading to c-jun activation. The TRAF associated protein ECSIT leads to c-Jun activation through the Map kinase/JNK signaling system. TRAF6 also signals through the TAB1/TAK1 kinases to trigger the degradation of I-kB, and activation of NF-kB. The IL-1 signaling cascade represents a highly conserved response to pathogens through evolution, with homologs in insects and even in plants. The signal transduction cascade utilized by IL-1 receptor is similar to that of TNF, resulting in NF-kB activation, and is most similar to that of the Toll-like receptors that also participate in inflammatory signaling responses to pathogen components like endotoxin." TAGS="" MEMBERS="BM458535,BQ948628,NM_000575,NM_000576,NM_000577,NM_000594,NM_000600,NM_000660,NM_000877,NM_001025242,NM_001025243,NM_001135599,NM_001142523,NM_001145138,NM_001165412,NM_001167928,NM_001167929,NM_001167930,NM_001167931,NM_001172566,NM_001172567,NM_001172568,NM_001172569,NM_001190720,NM_001242778,NM_001243984,NM_001243985,NM_001278,NM_001315,NM_001556,NM_001569,NM_001570,NM_002176,NM_002182,NM_002228,NM_002468,NM_002750,NM_002756,NM_002758,NM_003188,NM_003238,NM_003239,NM_003954,NM_003998,NM_004620,NM_005921,NM_006116,NM_007199,NM_020529,NM_021975,NM_024013,NM_134470,NM_139012,NM_139013,NM_139014,NM_139046,NM_139047,NM_139049,NM_145109,NM_145331,NM_145332,NM_145333,NM_145803,NM_153497,NM_173841,NM_173842,NM_173843" MEMBERS_SYMBOLIZED="CHUK,IFNA1,IFNB1,IKBKB,IL1A,IL1B,IL1R1,IL1RAP,IL1RN,IL6,IRAK1,IRAK2,IRAK3,JUN,MAP2K3,MAP2K6,MAP3K1,MAP3K14,MAP3K7,MAPK14,MAPK8,MYD88,NFKB1,NFKBIA,RELA,TAB1,TGFB1,TGFB2,TGFB3,TNF,TRAF6" MEMBERS_EZID="10454,11213,1147,1432,3439,3456,3551,3552,3553,3554,3556,3557,3569,3654,3656,3725,4214,4615,4790,4792,5599,5606,5608,5970,6885,7040,7042,7043,7124,7189,9020" MEMBERS_MAPPING="BM458535,null,null|BQ948628,null,null|NM_000575,IL1A,3552|NM_000576,IL1B,3553|NM_000577,IL1RN,3557|NM_000594,TNF,7124|NM_000600,IL6,3569|NM_000660,TGFB1,7040|NM_000877,IL1R1,3554|NM_001025242,IRAK1,3654|NM_001025243,IRAK1,3654|NM_001135599,TGFB2,7042|NM_001142523,IRAK3,11213|NM_001145138,RELA,5970|NM_001165412,NFKB1,4790|NM_001167928,IL1RAP,3556|NM_001167929,IL1RAP,3556|NM_001167930,IL1RAP,3556|NM_001167931,IL1RAP,3556|NM_001172566,MYD88,4615|NM_001172567,MYD88,4615|NM_001172568,MYD88,4615|NM_001172569,MYD88,4615|NM_001190720,IKBKB,3551|NM_001242778,IKBKB,3551|NM_001243984,RELA,5970|NM_001243985,RELA,5970|NM_001278,CHUK,1147|NM_001315,MAPK14,1432|NM_001556,IKBKB,3551|NM_001569,IRAK1,3654|NM_001570,IRAK2,3656|NM_002176,IFNB1,3456|NM_002182,IL1RAP,3556|NM_002228,JUN,3725|NM_002468,MYD88,4615|NM_002750,MAPK8,5599|NM_002756,MAP2K3,5606|NM_002758,MAP2K6,5608|NM_003188,MAP3K7,6885|NM_003238,TGFB2,7042|NM_003239,TGFB3,7043|NM_003954,MAP3K14,9020|NM_003998,NFKB1,4790|NM_004620,TRAF6,7189|NM_005921,MAP3K1,4214|NM_006116,TAB1,10454|NM_007199,IRAK3,11213|NM_020529,NFKBIA,4792|NM_021975,RELA,5970|NM_024013,IFNA1,3439|NM_134470,IL1RAP,3556|NM_139012,MAPK14,1432|NM_139013,MAPK14,1432|NM_139014,MAPK14,1432|NM_139046,MAPK8,5599|NM_139047,null,null|NM_139049,MAPK8,5599|NM_145109,MAP2K3,5606|NM_145331,MAP3K7,6885|NM_145332,MAP3K7,6885|NM_145333,MAP3K7,6885|NM_145803,TRAF6,7189|NM_153497,TAB1,10454|NM_173841,IL1RN,3557|NM_173842,IL1RN,3557|NM_173843,IL1RN,3557" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CP:BIOCARTA"/>
</MSIGDB>
