STANDARD_NAME	BIOCARTA_IL22BP_PATHWAY
SYSTEMATIC_NAME	M8066
COLLECTION	C2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_IL22BP_PATHWAY
NAMESPACE	Human_RefSeq
DESCRIPTION_BRIEF	IL22 Soluble Receptor Signaling Pathway
DESCRIPTION_FULL	IL-22 is an inflammatory cytokine related to IL-10 that is produced by T cells and that induces a response in cells through a heterodimeric cell surface receptor composed of IL-22R1 and IL-10R2C. One of the actions of IL-22 appears to be the induction of the acute phase inflammatory response in hetapocytes, acting through activation of STATs and transcriptional regulation. A gene with homology to the extracellular domain of the cell surface IL-22R1 receptor component was identified that lacked transmembrane and cytoplasmic domains. The protein derived from this gene was found to bind IL-22 and block its interaction with the cell surface receptor. The IL-22 soluble receptor (IL-22BP, IL-22 binding protein) also blocks some of the downstream effects of IL-22 such as STAT activation and the transcriptional induction of genes involved in the immune and inflammatory responses. The IL-22 soluble receptor may act as an anti-inflammatory agent.
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CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_il22bpPathway.gif
SOURCE_MEMBERS	BE617884,NM_000215,NM_002227,NM_003150,NM_003152,NM_003331,NM_003955,NM_004972,NM_007315,NM_012448,NM_139266,NM_139276,NM_213662
GENE_SYMBOLS	,JAK3,JAK1,STAT3,STAT5A,TYK2,SOCS3,JAK2,STAT1,STAT5B,STAT1,STAT3,STAT3
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