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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="BIOCARTA_IL22BP_PATHWAY" SYSTEMATIC_NAME="M8066" HISTORICAL_NAMES="" PMID="" AUTHORS="" GEOID="" EXACT_SOURCE="" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_il22bpPathway.gif" CHIP="Human_RefSeq" CONTRIBUTOR="BioCarta" CONTRIBUTOR_ORG="BioCarta" DESCRIPTION_BRIEF="IL22 Soluble Receptor Signaling Pathway" DESCRIPTION_FULL="IL-22 is an inflammatory cytokine related to IL-10 that is produced by T cells and that induces a response in cells through a heterodimeric cell surface receptor composed of IL-22R1 and IL-10R2C. One of the actions of IL-22 appears to be the induction of the acute phase inflammatory response in hetapocytes, acting through activation of STATs and transcriptional regulation. A gene with homology to the extracellular domain of the cell surface IL-22R1 receptor component was identified that lacked transmembrane and cytoplasmic domains. The protein derived from this gene was found to bind IL-22 and block its interaction with the cell surface receptor. The IL-22 soluble receptor (IL-22BP, IL-22 binding protein) also blocks some of the downstream effects of IL-22 such as STAT activation and the transcriptional induction of genes involved in the immune and inflammatory responses. The IL-22 soluble receptor may act as an anti-inflammatory agent." TAGS="" MEMBERS="BE617884,NM_000215,NM_002227,NM_003150,NM_003152,NM_003331,NM_003955,NM_004972,NM_007315,NM_012448,NM_139266,NM_139276,NM_213662" MEMBERS_SYMBOLIZED="JAK1,JAK2,JAK3,SOCS3,STAT1,STAT3,STAT5A,STAT5B,TYK2" MEMBERS_EZID="3716,3717,3718,6772,6774,6776,6777,7297,9021" MEMBERS_MAPPING="BE617884,null,null|NM_000215,JAK3,3718|NM_002227,JAK1,3716|NM_003150,STAT3,6774|NM_003152,STAT5A,6776|NM_003331,TYK2,7297|NM_003955,SOCS3,9021|NM_004972,JAK2,3717|NM_007315,STAT1,6772|NM_012448,STAT5B,6777|NM_139266,STAT1,6772|NM_139276,STAT3,6774|NM_213662,STAT3,6774" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CP:BIOCARTA"/>
</MSIGDB>
