STANDARD_NAME BIOCARTA_IL3_PATHWAY SYSTEMATIC_NAME M17681 COLLECTION C2:CP:BIOCARTA MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_IL3_PATHWAY NAMESPACE HUMAN_SEQ_ACCESSION DESCRIPTION_BRIEF IL 3 signaling pathway DESCRIPTION_FULL Interleukin-3 promotes the proliferation and differentiation of hematopoietic cells through binding to its receptor. The receptor for IL-3 is a heterodimer with a ligand-specific alpha chain (70 kD, CD123) and a common beta chain (shared with IL-5 and GM-CSF). Signaling is believed to be primarily through Stat5 and the MAPK pathways. PMID GEOID AUTHORS CONTRIBUTOR BioCarta CONTRIBUTOR_ORG BioCarta EXACT_SOURCE FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_il3Pathway.gif SOURCE_MEMBERS AL833457,NM_000395,NM_000588,NM_001040056,NM_001109891,NM_001130040,NM_001130041,NM_001130442,NM_001202859,NM_001267713,NM_002086,NM_002183,NM_002746,NM_002755,NM_002831,NM_002880,NM_003029,NM_003152,NM_004972,NM_005252,NM_005343,NM_005633,NM_012448,NM_080548,NM_080549,NM_176795,NM_183001,NM_203506 GENE_SYMBOLS SOS1,CSF2RB,IL3,MAPK3,MAPK3,SHC1,SHC1,HRAS,SHC1,IL3RA,GRB2,IL3RA,MAPK3,MAP2K1,PTPN6,RAF1,SHC1,STAT5A,JAK2,FOS,HRAS,SOS1,STAT5B,PTPN6,PTPN6,HRAS,SHC1,GRB2 FOUNDER_NAMES