STANDARD_NAME	BIOCARTA_IL5_PATHWAY
SYSTEMATIC_NAME	M18928
COLLECTION	C2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_IL5_PATHWAY
NAMESPACE	Human_RefSeq
DESCRIPTION_BRIEF	IL 5 Signaling Pathway
DESCRIPTION_FULL	IL-5 is an inflammatory signaling molecule that primarily stimulates eosinophil proliferation, maturation and activation. Eosinophils are leukocytes involved in inflammatory responses that defend against parasites and cause some aspects of asthma, allergic reactions, and perhaps autoimmune disorders. The action of IL-5 begins with an immune response in tissues, such as activation of macrophages and T cells that secrete IL-1, IL-4 and IL-6. The immune response can lead to IL-5 secretion by T cells, eosinophils and mast cells. Secreted IL-5 stimulates production and maturation of eosinophils in bone marrow that migrate to tissues in response to eotaxin and release factors that damage tissues, causing some of the undesirable consequences of inflammation. The receptor for IL-5 is a heterodimer of an alpha subunit that is required for IL-5 selective binding and a beta subunit that is also part of the IL-3 and GM-CSF receptors. Binding of IL-5 to the IL-5 receptor at the cell surface activates JAK/STAT signaling pathways that regulate transcription, proliferation, and differentiation.
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GEOID	
AUTHORS	
CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_il5Pathway.gif
SOURCE_MEMBERS	BG484513,NM_000564,NM_000576,NM_000589,NM_000600,NM_000616,NM_000879,NM_001164680,NM_001195014,NM_001195015,NM_001195016,NM_001195017,NM_001243099,NM_001243965,NM_001837,NM_002124,NM_002125,NM_002986,NM_019111,NM_021983,NM_022555,NM_172348,NM_175724,NM_175725,NM_175726,NM_175727,NM_175728,NM_178328,NM_178329
GENE_SYMBOLS	,IL5RA,IL1B,IL4,IL6,CD4,IL5,CCR3,CD4,CD4,CD4,CD4,IL5RA,HLA-DRB1,CCR3,HLA-DRB1,HLA-DRB5,CCL11,HLA-DRA,HLA-DRB4,HLA-DRB3,IL4,IL5RA,IL5RA,IL5RA,IL5RA,IL5RA,CCR3,CCR3
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