STANDARD_NAME	BIOCARTA_LECTIN_PATHWAY
SYSTEMATIC_NAME	M4732
COLLECTION	C2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_LECTIN_PATHWAY
NAMESPACE	Human_RefSeq
DESCRIPTION_BRIEF	Lectin Induced Complement Pathway
DESCRIPTION_FULL	The complement cascade of proteolytic factors involved in cellular lysis can be initiated by several different factors, including antibody-dependent and antibody-independent recognition of infectious organisms. In the lectin-induced complement cascade, carbohydrates on the surface of microbial cells activate the complement cascade by binding to mannan-binding lectin (also called the mannan-binding protein, Mbl/Mbp). Mbp is an acute phase serum protein whose expression is induced by microbial infection. The binding of Mbl to microbial ligands activates the Mbl associated serine proteases Masp1 and Masp2, triggering the cleavage of C2 and C4 to create C4bC2a, a C3 convertase that cleaves large numbers of C3. Masp1 and Masp2 are similar to the C1 protease in the classical complement pathway. Once formed the C3 convertase cleaves and activates the remaining complement factors leading ultimately to formation of a pore in the bacterial membrane by the membrane attack complex (MAC) that lyses the bacterial cell. The lectin-induced pathway also appears to play an important role of the activation of phagocytotic cells by infection. Although the initiating event activating the complement cascade is distinct in the lectin-induced pathway, from the C3 convertase onward the lectin induced complement pathway is the same as the classical complement pathway. Since antibodies are not required in the lectin-induced pathway, this aspect of the immune response is part of the innate immune response. The importance of this pathway to the immune response has been demonstrated by the identification of children and adults with little or no Mbl who lacked normal phagocytotic responses and are highly susceptible to infection.
PMID	
GEOID	
AUTHORS	
CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_lectinPathway.gif
SOURCE_MEMBERS	NM_000063,NM_000064,NM_000065,NM_000242,NM_000562,NM_000587,NM_001002029,NM_001031849,NM_001115131,NM_001145903,NM_001178063,NM_001242823,NM_001252204,NM_001735,NM_001737,NM_001879,NM_006610,NM_007293,NM_139125,NM_139208
GENE_SYMBOLS	C2,C3,C6,MBL2,C8A,C7,C4B,MASP1,C6,C2,C2,C4B_2,C4A,C5,C9,MASP1,MASP2,C4A,MASP1,MASP2
FOUNDER_NAMES