STANDARD_NAME	BIOCARTA_MITOCHONDRIA_PATHWAY
SYSTEMATIC_NAME	M16257
COLLECTION	C2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_MITOCHONDRIA_PATHWAY
NAMESPACE	Human_RefSeq
DESCRIPTION_BRIEF	Role of Mitochondria in Apoptotic Signaling
DESCRIPTION_FULL	Mitochondria participate in apoptotic signaling pathways through the release of mitochondrial proteins into the cytoplasm. Cytochrome c, a key protein in electron transport, is released from mitochondria in response to apoptotic signals, and activates Apaf-1, a protease released from mitochondria. Activated Apaf-1 activates caspase-9 and the rest of the caspase pathway. Smac/DIABLO is released from mitochondria and inhibits IAP proteins that normally interact with caspase-9 to inhibit apoptosis. Apoptosis regulation by Bcl-2 family proteins occurs as family members form complexes that enter the mitochondrial membrane, regulating the release of cytochrome c and other proteins. TNF family receptor that cause apoptosis directly activate the caspase cascade, but can also activate Bid, a Bcl-2 family member, which activates mitochondria-mediated apoptosis. Bax, another Bcl-2 family member, is activated by this pathway to localize to the mitochondrial membrane and increase its permeability, releasing cytochre c and other mitochondrial proteins. Bcl-2 and Bcl-xL prevent pore formation, blocking apoptosis. AIF (Apoptosis inducing factor) is another mitochondrial factor that is released into the cytoplasm to induce apoptosis. AIF-induced apoptosis is important during development but is not caspase dependent.
PMID	
GEOID	
AUTHORS	
CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_mitochondriaPathway.gif
SOURCE_MEMBERS	AU077055,BM459898,NM_000633,NM_000657,NM_001080124,NM_001080125,NM_001130846,NM_001130847,NM_001160,NM_001165,NM_001166,NM_001167,NM_001188,NM_001196,NM_001197,NM_001204401,NM_001226,NM_001227,NM_001228,NM_001229,NM_001244567,NM_001244569,NM_001244570,NM_001244572,NM_001256163,NM_001256166,NM_001267056,NM_001267057,NM_001267058,NM_004208,NM_004324,NM_004346,NM_004401,NM_004402,NM_004435,NM_013229,NM_019887,NM_032991,NM_032992,NM_032996,NM_033338,NM_033339,NM_033340,NM_033355,NM_033356,NM_033358,NM_138761,NM_138763,NM_138764,NM_138929,NM_145812,NM_145813,NM_181861,NM_181868,NM_181869,NM_182962,NM_197966,NM_197967,NM_213566
GENE_SYMBOLS	,,BCL2,BCL2,CASP8,CASP8,AIFM1,AIFM1,APAF1,BIRC3,BIRC2,XIAP,BAK1,BID,BIK,XIAP,CASP6,CASP7,CASP8,CASP9,BID,BID,BID,BID,BIRC2,BIRC2,CASP7,CASP7,CASP7,AIFM1,BAX,CASP3,DFFA,DFFB,ENDOG,APAF1,DIABLO,CASP3,CASP6,CASP9,CASP7,CASP7,CASP7,CASP8,CASP8,CASP8,BAX,BAX,BAX,DIABLO,AIFM1,AIFM1,APAF1,APAF1,APAF1,BIRC3,BID,BID,DFFA
FOUNDER_NAMES