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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="BIOCARTA_MITOCHONDRIA_PATHWAY" SYSTEMATIC_NAME="M16257" HISTORICAL_NAMES="" PMID="" AUTHORS="" GEOID="" EXACT_SOURCE="" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_mitochondriaPathway.gif" CHIP="Human_RefSeq" CONTRIBUTOR="BioCarta" CONTRIBUTOR_ORG="BioCarta" DESCRIPTION_BRIEF="Role of Mitochondria in Apoptotic Signaling" DESCRIPTION_FULL="Mitochondria participate in apoptotic signaling pathways through the release of mitochondrial proteins into the cytoplasm. Cytochrome c, a key protein in electron transport, is released from mitochondria in response to apoptotic signals, and activates Apaf-1, a protease released from mitochondria. Activated Apaf-1 activates caspase-9 and the rest of the caspase pathway. Smac/DIABLO is released from mitochondria and inhibits IAP proteins that normally interact with caspase-9 to inhibit apoptosis. Apoptosis regulation by Bcl-2 family proteins occurs as family members form complexes that enter the mitochondrial membrane, regulating the release of cytochrome c and other proteins. TNF family receptor that cause apoptosis directly activate the caspase cascade, but can also activate Bid, a Bcl-2 family member, which activates mitochondria-mediated apoptosis. Bax, another Bcl-2 family member, is activated by this pathway to localize to the mitochondrial membrane and increase its permeability, releasing cytochre c and other mitochondrial proteins. Bcl-2 and Bcl-xL prevent pore formation, blocking apoptosis. AIF (Apoptosis inducing factor) is another mitochondrial factor that is released into the cytoplasm to induce apoptosis. AIF-induced apoptosis is important during development but is not caspase dependent." TAGS="" MEMBERS="AU077055,BM459898,NM_000633,NM_000657,NM_001080124,NM_001080125,NM_001130846,NM_001130847,NM_001160,NM_001165,NM_001166,NM_001167,NM_001188,NM_001196,NM_001197,NM_001204401,NM_001226,NM_001227,NM_001228,NM_001229,NM_001244567,NM_001244569,NM_001244570,NM_001244572,NM_001256163,NM_001256166,NM_001267056,NM_001267057,NM_001267058,NM_004208,NM_004324,NM_004346,NM_004401,NM_004402,NM_004435,NM_013229,NM_019887,NM_032991,NM_032992,NM_032996,NM_033338,NM_033339,NM_033340,NM_033355,NM_033356,NM_033358,NM_138761,NM_138763,NM_138764,NM_138929,NM_145812,NM_145813,NM_181861,NM_181868,NM_181869,NM_182962,NM_197966,NM_197967,NM_213566" MEMBERS_SYMBOLIZED="AIFM1,APAF1,BAK1,BAX,BCL2,BID,BIK,BIRC2,BIRC3,CASP3,CASP6,CASP7,CASP8,CASP9,DFFA,DFFB,DIABLO,ENDOG,XIAP" MEMBERS_EZID="1676,1677,2021,317,329,330,331,56616,578,581,596,637,638,836,839,840,841,842,9131" MEMBERS_MAPPING="AU077055,null,null|BM459898,null,null|NM_000633,BCL2,596|NM_000657,BCL2,596|NM_001080124,CASP8,841|NM_001080125,CASP8,841|NM_001130846,AIFM1,9131|NM_001130847,AIFM1,9131|NM_001160,APAF1,317|NM_001165,BIRC3,330|NM_001166,BIRC2,329|NM_001167,XIAP,331|NM_001188,BAK1,578|NM_001196,BID,637|NM_001197,BIK,638|NM_001204401,XIAP,331|NM_001226,CASP6,839|NM_001227,CASP7,840|NM_001228,CASP8,841|NM_001229,CASP9,842|NM_001244567,BID,637|NM_001244569,BID,637|NM_001244570,BID,637|NM_001244572,BID,637|NM_001256163,BIRC2,329|NM_001256166,BIRC2,329|NM_001267056,CASP7,840|NM_001267057,CASP7,840|NM_001267058,CASP7,840|NM_004208,AIFM1,9131|NM_004324,BAX,581|NM_004346,CASP3,836|NM_004401,DFFA,1676|NM_004402,DFFB,1677|NM_004435,ENDOG,2021|NM_013229,APAF1,317|NM_019887,DIABLO,56616|NM_032991,CASP3,836|NM_032992,CASP6,839|NM_032996,CASP9,842|NM_033338,CASP7,840|NM_033339,CASP7,840|NM_033340,CASP7,840|NM_033355,CASP8,841|NM_033356,CASP8,841|NM_033358,CASP8,841|NM_138761,BAX,581|NM_138763,BAX,581|NM_138764,BAX,581|NM_138929,DIABLO,56616|NM_145812,AIFM1,9131|NM_145813,AIFM1,9131|NM_181861,APAF1,317|NM_181868,APAF1,317|NM_181869,APAF1,317|NM_182962,BIRC3,330|NM_197966,BID,637|NM_197967,BID,637|NM_213566,DFFA,1676" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CP:BIOCARTA"/>
</MSIGDB>
