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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="BIOCARTA_NFKB_PATHWAY" SYSTEMATIC_NAME="M15285" HISTORICAL_NAMES="" PMID="" AUTHORS="" GEOID="" EXACT_SOURCE="" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_nfkbPathway.gif" CHIP="Human_RefSeq" CONTRIBUTOR="BioCarta" CONTRIBUTOR_ORG="BioCarta" DESCRIPTION_BRIEF="NF-kB Signaling Pathway" DESCRIPTION_FULL="Nuclear factor kB (NF-kB) is a nuclear transcription factor that regulates expression of a large number of genes that are critical for the regulation of apoptosis, viral replication, tumorigenesis, inflammation, and various autoimmune diseases. The activation of NF-kB is thought to be part of a stress response as it is activated by a variety of stimuli that include growth factors, cytokines, lymphokines, UV, pharmacological agents, and stress. In its inactive form, NF-kB is sequestered in the cytoplasm, bound by members of the IkB family of inhibitor proteins, which include IkBa, IkBb, IkBg, and IkBe. The various stimuli that activate NF-kB cause phosphorylation of IkB, which is followed by its ubiquitination and subsequent degradation. This results in the exposure of the nuclear localization signals (NLS) on NF-kB subunits and the subsequent translocation of the molecule to the nucleus. In the nucleus, NF-kB binds with a consensus sequence (5'GGGACTTTCC-3') of various genes and thus activates their transcription. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins; IKK1/IKKa, IKK2/IKKb, and IKK3/IKKg. These enzymes phosphorylate IkB leading to its ubiquitination and degradation. Tumor necrosis factor (TNF) which is the best-studied activator binds to its receptor and recruits a protein called TNF receptor death domain (TRADD). TRADD binds to the TNF receptor-associated factor 2 (TRAF-2) that recruits NF-kB-inducible kinase (NIK). Both IKK1 and IKK2 have canonical sequences that can be phosphorylated by the MAP kinase NIK/MEKK1 and both kinases can independently phosphorylate IkBa or IkBb. TRAF-2 also interacts with A20, a zinc finger protein whose expression is induced by agents that activate NF-kB. A20 functions to block TRAF2-mediated NF-kB activation. A20 also inhibits TNF and IL-1 induced activation of NF-kB suggesting that it may act as a general inhibitor of NF-kB activation." TAGS="" MEMBERS="BM458535,BQ948628,NM_000575,NM_000594,NM_000877,NM_001065,NM_001066,NM_001099856,NM_001099857,NM_001145138,NM_001145255,NM_001165412,NM_001172566,NM_001172567,NM_001172568,NM_001172569,NM_001190720,NM_001242778,NM_001243984,NM_001243985,NM_001270507,NM_001270508,NM_001278,NM_001556,NM_002468,NM_003188,NM_003639,NM_003789,NM_003804,NM_003824,NM_003954,NM_003998,NM_004620,NM_005921,NM_006116,NM_006290,NM_020529,NM_021975,NM_145331,NM_145332,NM_145333,NM_145803,NM_153497" MEMBERS_SYMBOLIZED="CHUK,FADD,IKBKB,IKBKG,IL1A,IL1R1,MAP3K1,MAP3K14,MAP3K7,MYD88,NFKB1,NFKBIA,RELA,RIPK1,TAB1,TNF,TNFAIP3,TNFRSF1A,TNFRSF1B,TRADD,TRAF6" MEMBERS_EZID="10454,1147,3551,3552,3554,4214,4615,4790,4792,5970,6885,7124,7128,7132,7133,7189,8517,8717,8737,8772,9020" MEMBERS_MAPPING="BM458535,null,null|BQ948628,null,null|NM_000575,IL1A,3552|NM_000594,TNF,7124|NM_000877,IL1R1,3554|NM_001065,TNFRSF1A,7132|NM_001066,TNFRSF1B,7133|NM_001099856,IKBKG,8517|NM_001099857,IKBKG,8517|NM_001145138,RELA,5970|NM_001145255,IKBKG,8517|NM_001165412,NFKB1,4790|NM_001172566,MYD88,4615|NM_001172567,MYD88,4615|NM_001172568,MYD88,4615|NM_001172569,MYD88,4615|NM_001190720,IKBKB,3551|NM_001242778,IKBKB,3551|NM_001243984,RELA,5970|NM_001243985,RELA,5970|NM_001270507,TNFAIP3,7128|NM_001270508,TNFAIP3,7128|NM_001278,CHUK,1147|NM_001556,IKBKB,3551|NM_002468,MYD88,4615|NM_003188,MAP3K7,6885|NM_003639,IKBKG,8517|NM_003789,TRADD,8717|NM_003804,RIPK1,8737|NM_003824,FADD,8772|NM_003954,MAP3K14,9020|NM_003998,NFKB1,4790|NM_004620,TRAF6,7189|NM_005921,MAP3K1,4214|NM_006116,TAB1,10454|NM_006290,TNFAIP3,7128|NM_020529,NFKBIA,4792|NM_021975,RELA,5970|NM_145331,MAP3K7,6885|NM_145332,MAP3K7,6885|NM_145333,MAP3K7,6885|NM_145803,TRAF6,7189|NM_153497,TAB1,10454" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CP:BIOCARTA"/>
</MSIGDB>
