STANDARD_NAME BIOCARTA_P38MAPK_PATHWAY SYSTEMATIC_NAME M862 COLLECTION C2:CP:BIOCARTA MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_P38MAPK_PATHWAY NAMESPACE HUMAN_SEQ_ACCESSION DESCRIPTION_BRIEF p38 MAPK Signaling Pathway DESCRIPTION_FULL p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activated MKK3/5, the p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, THE Max/Myc complex, MEF-2, ELK-1 and indirectly CREB via activation of MSK1. PMID GEOID AUTHORS CONTRIBUTOR BioCarta CONTRIBUTOR_ORG BioCarta EXACT_SOURCE FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_p38mapkPathway.gif SOURCE_MEMBERS AA522690,AK123430,BE617884,BG682876,BQ877285,NM_000660,NM_001039802,NM_001114123,NM_001130040,NM_001130041,NM_001130442,NM_001130916,NM_001135553,NM_001135599,NM_001141969,NM_001141970,NM_001195053,NM_001195054,NM_001195055,NM_001195056,NM_001195057,NM_001202859,NM_001254717,NM_001256090,NM_001256091,NM_001256092,NM_001256093,NM_001256094,NM_001257168,NM_001271068,NM_001271069,NM_001315,NM_001350,NM_001540,NM_001541,NM_001791,NM_001880,NM_002086,NM_002382,NM_002467,NM_002758,NM_003010,NM_003029,NM_003188,NM_003238,NM_003239,NM_003668,NM_003684,NM_003789,NM_003804,NM_004083,NM_004379,NM_004612,NM_004755,NM_004759,NM_004965,NM_005229,NM_005343,NM_005921,NM_005923,NM_006908,NM_007315,NM_014247,NM_018890,NM_021138,NM_024420,NM_032960,NM_033141,NM_044472,NM_134442,NM_139012,NM_139013,NM_139014,NM_139078,NM_139266,NM_145112,NM_145113,NM_145114,NM_145331,NM_145332,NM_145333,NM_176795,NM_182398,NM_183001,NM_197957,NM_198973,NM_203506 GENE_SYMBOLS ,MAP3K9,,,,TGFB1,CDC42,ELK1,SHC1,SHC1,HRAS,TGFBR1,MKNK1,TGFB2,DAXX,DAXX,DDIT3,DDIT3,DDIT3,DDIT3,DDIT3,SHC1,DAXX,ATF2,ATF2,ATF2,ATF2,ATF2,ELK1,MAX,MAX,MAPK14,DAXX,HSPB1,HSPB2,CDC42,ATF2,GRB2,MAX,MYC,MAP2K6,MAP2K4,SHC1,MAP3K7,TGFB2,TGFB3,MAPKAPK5,MKNK1,TRADD,RIPK1,DDIT3,CREB1,TGFBR1,RPS6KA5,MAPKAPK2,HMGN1,ELK1,HRAS,MAP3K1,MAP3K5,RAC1,STAT1,RAPGEF2,RAC1,TRAF2,PLA2G4A,MAPKAPK2,MAP3K9,CDC42,CREB1,MAPK14,MAPK14,MAPK14,MAPKAPK5,STAT1,MAX,MAX,MAX,MAP3K7,MAP3K7,MAP3K7,HRAS,RPS6KA5,SHC1,MAX,MKNK1,GRB2 FOUNDER_NAMES