STANDARD_NAME	BIOCARTA_PROTEASOME_PATHWAY
SYSTEMATIC_NAME	M194
COLLECTION	C2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_PROTEASOME_PATHWAY
NAMESPACE	Human_NCBI_Gene_ID
DESCRIPTION_BRIEF	Proteasome Complex
DESCRIPTION_FULL	Attachment of the ubiquitin peptide to proteins targets them for proteolytic degradation by a complex cellular structure, the proteasome. The regulated proteolysis of proteins by proteasomes removes denatured, damaged or improperly translated proteins from cells and regulates the level of proteins like cyclins or some transcription factors. E1 and E2 enzymes prepare ubiquitin chains that are then attached to proteins by the E3 enzyme. The sequence of ubiquitin and the basic structure and function of the proteasome are highly conserved. The core proteasome in man (20S proteasome) consists of four rings each with 14 subunits stacked on top of each other that are responsible for the proteolytic activity of the proteasome. The PA700 regulatory complex is stacked on the ends of the cylindrical core to form a 26S proteasome. Proteins that are tagged with ubiquitin are recognized and bound by the regulatory subunits, then unfolded in an ATP-dependent manner, and inserted into the core particle, where proteases degrade the protein, releasing small peptides and releasing the ubiquitin intact. The PA28 regulatory complex is alternative regulatory complex that appears to play a role in antigen processing for presentation of peptides to immune cells in the MHC I complex.
PMID	
GEOID	
AUTHORS	
CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	http://cgap.nci.nih.gov/Pathways/BioCarta/proteasomePathway
SOURCE_MEMBERS	25596,31567,32047,33738,35701,36638,39845,40717,42641,42805,5682,5683,5684,5685,5686,5687,5688,5689,5690,5691,5692,5693,5694,5695,6184,6185,7317,7319,7337
GENE_SYMBOLS	RPN1,,,,,,,,,,PSMA1,PSMA2,PSMA3,PSMA4,PSMA5,PSMA6,PSMA7,PSMB1,PSMB2,PSMB3,PSMB4,PSMB5,PSMB6,PSMB7,RPN1,RPN2,UBA1,UBE2A,UBE3A
FOUNDER_NAMES