STANDARD_NAME BIOCARTA_PTEN_PATHWAY SYSTEMATIC_NAME M10145 COLLECTION C2:CP:BIOCARTA MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_PTEN_PATHWAY NAMESPACE HUMAN_SEQ_ACCESSION DESCRIPTION_BRIEF PTEN dependent cell cycle arrest and apoptosis DESCRIPTION_FULL PTEN is a tumor suppressor gene. Recombinant PTEN is capable of dephosphorylating phosphatidylinositol 3,4,5-triphosphate, the product of phosphatidylinositol 3 -kinase. Many of the cancer-related mutations have been mapped to the phosphatase catalytic domain, it has been suggested that the phosphatase activity of PTEN is required for its tumor suppressor function. The activation of PKB/AKT is regulated in a complex manner via phosphorylation of AKT on Thr308 and Ser473 by PDK1 and ILK(integrin-linked kinase) respectively. Inactivation of PTEN will constitutively activate PKB/AKT pathway. In addition to its role in regulating the PI 3-K/AKT cell survival pathway, PTEN also inhibits growth factor-induced Shc phosphorylation and suppresses the mitogen-activated protein (MAP) kinase signaling pathway. PTEN also interact with FAK, a key molecule implicated in integrin signaling pathways, and it directly dephosphorylates tyrosine-phosphorylated FAK. PTEN down-regulation of p130CAS through FAK results in inhibition of cell migration and spreading. PMID GEOID AUTHORS CONTRIBUTOR BioCarta CONTRIBUTOR_ORG BioCarta EXACT_SOURCE FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_ptenPathway.gif SOURCE_MEMBERS AI334281,AK021510,AL833457,BM458681,NM_000314,NM_000639,NM_001014431,NM_001014432,NM_001014794,NM_001014795,NM_001040056,NM_001109891,NM_001130040,NM_001130041,NM_001170714,NM_001170715,NM_001170716,NM_001170717,NM_001170718,NM_001170719,NM_001170720,NM_001170721,NM_001199898,NM_001199899,NM_001199900,NM_001202859,NM_001242466,NM_001261816,NM_001455,NM_002086,NM_002211,NM_002611,NM_002613,NM_002745,NM_002746,NM_003029,NM_004064,NM_004517,NM_005163,NM_005228,NM_005633,NM_006218,NM_014567,NM_031268,NM_033668,NM_133376,NM_138957,NM_181504,NM_181523,NM_181524,NM_183001,NM_201282,NM_201283,NM_201284,NM_201559,NM_203506 GENE_SYMBOLS PIK3R1,PIK3CA,SOS1,,PTEN,FASLG,AKT1,AKT1,ILK,ILK,MAPK3,MAPK3,SHC1,SHC1,BCAR1,BCAR1,BCAR1,BCAR1,BCAR1,BCAR1,BCAR1,BCAR1,PDK2,PDK2,PDK2,SHC1,PIK3R1,PDPK1,FOXO3,GRB2,ITGB1,PDK2,PDPK1,MAPK1,MAPK3,SHC1,CDKN1B,ILK,AKT1,EGFR,SOS1,PIK3CA,BCAR1,PDPK1,ITGB1,ITGB1,MAPK1,PIK3R1,PIK3R1,PIK3R1,SHC1,EGFR,EGFR,EGFR,FOXO3,GRB2 FOUNDER_NAMES