STANDARD_NAME	BIOCARTA_PTEN_PATHWAY
SYSTEMATIC_NAME	M10145
COLLECTION	C2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_PTEN_PATHWAY
NAMESPACE	HUMAN_SEQ_ACCESSION
DESCRIPTION_BRIEF	PTEN dependent cell cycle arrest and apoptosis
DESCRIPTION_FULL	PTEN is a tumor suppressor gene. Recombinant PTEN is capable of dephosphorylating phosphatidylinositol 3,4,5-triphosphate, the product of phosphatidylinositol 3 -kinase. Many of the cancer-related mutations have been mapped to the phosphatase catalytic domain, it has been suggested that the phosphatase activity of PTEN is required for its tumor suppressor function. The activation of PKB/AKT is regulated in a complex manner via phosphorylation of AKT on Thr308 and Ser473 by PDK1 and ILK(integrin-linked kinase) respectively. Inactivation of PTEN will constitutively activate PKB/AKT pathway. In addition to its role in regulating the PI 3-K/AKT cell survival pathway, PTEN also inhibits growth factor-induced Shc phosphorylation and suppresses the mitogen-activated protein (MAP) kinase signaling pathway. PTEN also interact with FAK, a key molecule implicated in integrin signaling pathways, and it directly dephosphorylates tyrosine-phosphorylated FAK. PTEN down-regulation of p130CAS through FAK results in inhibition of cell migration and spreading.
PMID	
GEOID	
AUTHORS	
CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_ptenPathway.gif
SOURCE_MEMBERS	AI334281,AK021510,AL833457,BM458681,NM_000314,NM_000639,NM_001014431,NM_001014432,NM_001014794,NM_001014795,NM_001040056,NM_001109891,NM_001130040,NM_001130041,NM_001170714,NM_001170715,NM_001170716,NM_001170717,NM_001170718,NM_001170719,NM_001170720,NM_001170721,NM_001199898,NM_001199899,NM_001199900,NM_001202859,NM_001242466,NM_001261816,NM_001455,NM_002086,NM_002211,NM_002611,NM_002613,NM_002745,NM_002746,NM_003029,NM_004064,NM_004517,NM_005163,NM_005228,NM_005633,NM_006218,NM_014567,NM_031268,NM_033668,NM_133376,NM_138957,NM_181504,NM_181523,NM_181524,NM_183001,NM_201282,NM_201283,NM_201284,NM_201559,NM_203506
GENE_SYMBOLS	PIK3R1,PIK3CA,SOS1,,PTEN,FASLG,AKT1,AKT1,ILK,ILK,MAPK3,MAPK3,SHC1,SHC1,BCAR1,BCAR1,BCAR1,BCAR1,BCAR1,BCAR1,BCAR1,BCAR1,PDK2,PDK2,PDK2,SHC1,PIK3R1,PDPK1,FOXO3,GRB2,ITGB1,PDK2,PDPK1,MAPK1,MAPK3,SHC1,CDKN1B,ILK,AKT1,EGFR,SOS1,PIK3CA,BCAR1,PDPK1,ITGB1,ITGB1,MAPK1,PIK3R1,PIK3R1,PIK3R1,SHC1,EGFR,EGFR,EGFR,FOXO3,GRB2
FOUNDER_NAMES