STANDARD_NAME	BIOCARTA_PYK2_PATHWAY
SYSTEMATIC_NAME	M7739
COLLECTION	C2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_PYK2_PATHWAY
NAMESPACE	HUMAN_SEQ_ACCESSION
DESCRIPTION_BRIEF	Links between Pyk2 and Map Kinases
DESCRIPTION_FULL	This diagram is a compilation of Pyk2 effort cascades. In specific cell types the receptor and effoectors will vary. Binding of a transmembrane receptor triggers the activation of Ca2+ signaling and PKC. The signal is then transmitted to Pyk2 and further to the small G protein Rac1. In turn, Rac1 initiatates the JNK cascade, starting with PAK follwed by MEKK1, SEK1, and JNK. JNK activation causes induction of c-Jun gene binding. Pyk2 stimulation has also been shown to activate MKK3 leading to activation of p38. The other major mitogen activated kinase cascade for ERK1/2 is stimulated via RAS, RAF and MEKK1/2.
PMID	
GEOID	
AUTHORS	
CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_pyk2Pathway.gif
SOURCE_MEMBERS	AK055431,AL833457,BF795331,BQ218507,NM_001040056,NM_001109891,NM_001128620,NM_001130040,NM_001130041,NM_001130442,NM_001170714,NM_001170715,NM_001170716,NM_001170717,NM_001170718,NM_001170719,NM_001170720,NM_001170721,NM_001202859,NM_001315,NM_001743,NM_002072,NM_002086,NM_002228,NM_002576,NM_002660,NM_002737,NM_002738,NM_002745,NM_002746,NM_002750,NM_002755,NM_002756,NM_002880,NM_003010,NM_003029,NM_004103,NM_005184,NM_005207,NM_005343,NM_005633,NM_005921,NM_006888,NM_006908,NM_014567,NM_018890,NM_030662,NM_138957,NM_139012,NM_139013,NM_139014,NM_139046,NM_139047,NM_139049,NM_145109,NM_173174,NM_173175,NM_173176,NM_176795,NM_182811,NM_183001,NM_203506,NM_212535
GENE_SYMBOLS	PRKCA,SOS1,,CALM1,MAPK3,MAPK3,PAK1,SHC1,SHC1,HRAS,BCAR1,BCAR1,BCAR1,BCAR1,BCAR1,BCAR1,BCAR1,BCAR1,SHC1,MAPK14,CALM2,GNAQ,GRB2,JUN,PAK1,PLCG1,PRKCA,PRKCB,MAPK1,MAPK3,MAPK8,MAP2K1,MAP2K3,RAF1,MAP2K4,SHC1,PTK2B,CALM3,CRKL,HRAS,SOS1,MAP3K1,CALM1,RAC1,BCAR1,RAC1,MAP2K2,MAPK1,MAPK14,MAPK14,MAPK14,MAPK8,,MAPK8,MAP2K3,PTK2B,PTK2B,PTK2B,HRAS,PLCG1,SHC1,GRB2,PRKCB
FOUNDER_NAMES