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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="BIOCARTA_PYK2_PATHWAY" SYSTEMATIC_NAME="M7739" HISTORICAL_NAMES="" PMID="" AUTHORS="" GEOID="" EXACT_SOURCE="" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_pyk2Pathway.gif" CHIP="HUMAN_SEQ_ACCESSION" CONTRIBUTOR="BioCarta" CONTRIBUTOR_ORG="BioCarta" DESCRIPTION_BRIEF="Links between Pyk2 and Map Kinases" DESCRIPTION_FULL="This diagram is a compilation of Pyk2 effort cascades. In specific cell types the receptor and effoectors will vary. Binding of a transmembrane receptor triggers the activation of Ca2+ signaling and PKC. The signal is then transmitted to Pyk2 and further to the small G protein Rac1. In turn, Rac1 initiatates the JNK cascade, starting with PAK follwed by MEKK1, SEK1, and JNK. JNK activation causes induction of c-Jun gene binding. Pyk2 stimulation has also been shown to activate MKK3 leading to activation of p38. The other major mitogen activated kinase cascade for ERK1/2 is stimulated via RAS, RAF and MEKK1/2." TAGS="" MEMBERS="AK055431,AL833457,BF795331,BQ218507,NM_001040056,NM_001109891,NM_001128620,NM_001130040,NM_001130041,NM_001130442,NM_001170714,NM_001170715,NM_001170716,NM_001170717,NM_001170718,NM_001170719,NM_001170720,NM_001170721,NM_001202859,NM_001315,NM_001743,NM_002072,NM_002086,NM_002228,NM_002576,NM_002660,NM_002737,NM_002738,NM_002745,NM_002746,NM_002750,NM_002755,NM_002756,NM_002880,NM_003010,NM_003029,NM_004103,NM_005184,NM_005207,NM_005343,NM_005633,NM_005921,NM_006888,NM_006908,NM_014567,NM_018890,NM_030662,NM_138957,NM_139012,NM_139013,NM_139014,NM_139046,NM_139047,NM_139049,NM_145109,NM_173174,NM_173175,NM_173176,NM_176795,NM_182811,NM_183001,NM_203506,NM_212535" MEMBERS_SYMBOLIZED="BCAR1,CALM1,CALM2,CALM3,CRKL,GNAQ,GRB2,HRAS,JUN,MAP2K1,MAP2K2,MAP2K3,MAP2K4,MAP3K1,MAPK1,MAPK14,MAPK3,MAPK8,PAK1,PLCG1,PRKCA,PRKCB,PTK2B,RAC1,RAF1,SHC1,SOS1" MEMBERS_EZID="1399,1432,2185,2776,2885,3265,3725,4214,5058,5335,5578,5579,5594,5595,5599,5604,5605,5606,5879,5894,6416,6464,6654,801,805,808,9564" MEMBERS_MAPPING="AK055431,PRKCA,5578|AL833457,SOS1,6654|BF795331,null,null|BQ218507,CALM1,801|NM_001040056,MAPK3,5595|NM_001109891,MAPK3,5595|NM_001128620,PAK1,5058|NM_001130040,SHC1,6464|NM_001130041,SHC1,6464|NM_001130442,HRAS,3265|NM_001170714,BCAR1,9564|NM_001170715,BCAR1,9564|NM_001170716,BCAR1,9564|NM_001170717,BCAR1,9564|NM_001170718,BCAR1,9564|NM_001170719,BCAR1,9564|NM_001170720,BCAR1,9564|NM_001170721,BCAR1,9564|NM_001202859,SHC1,6464|NM_001315,MAPK14,1432|NM_001743,CALM2,805|NM_002072,GNAQ,2776|NM_002086,GRB2,2885|NM_002228,JUN,3725|NM_002576,PAK1,5058|NM_002660,PLCG1,5335|NM_002737,PRKCA,5578|NM_002738,PRKCB,5579|NM_002745,MAPK1,5594|NM_002746,MAPK3,5595|NM_002750,MAPK8,5599|NM_002755,MAP2K1,5604|NM_002756,MAP2K3,5606|NM_002880,RAF1,5894|NM_003010,MAP2K4,6416|NM_003029,SHC1,6464|NM_004103,PTK2B,2185|NM_005184,CALM3,808|NM_005207,CRKL,1399|NM_005343,HRAS,3265|NM_005633,SOS1,6654|NM_005921,MAP3K1,4214|NM_006888,CALM1,801|NM_006908,RAC1,5879|NM_014567,BCAR1,9564|NM_018890,RAC1,5879|NM_030662,MAP2K2,5605|NM_138957,MAPK1,5594|NM_139012,MAPK14,1432|NM_139013,MAPK14,1432|NM_139014,MAPK14,1432|NM_139046,MAPK8,5599|NM_139047,null,null|NM_139049,MAPK8,5599|NM_145109,MAP2K3,5606|NM_173174,PTK2B,2185|NM_173175,PTK2B,2185|NM_173176,PTK2B,2185|NM_176795,HRAS,3265|NM_182811,PLCG1,5335|NM_183001,SHC1,6464|NM_203506,GRB2,2885|NM_212535,PRKCB,5579" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CP:BIOCARTA"/>
</MSIGDB>
