STANDARD_NAME	BIOCARTA_RB_PATHWAY
SYSTEMATIC_NAME	M18159
COLLECTION	C2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_RB_PATHWAY
NAMESPACE	HUMAN_SEQ_ACCESSION
DESCRIPTION_BRIEF	RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage
DESCRIPTION_FULL	Cell cycle checkpoint controls at the G1 to S transition and the G2 to M transition prevent the cell cycle from progressing when DNA is damaged. The ATM protein kinase detects DNA damage and in response to this activates DNA repair factors and inhibits cell cycle progression. Two of the proteins that ATM phosphorylates in response to DNA damage are the tumor suppressor p53 and the checkpoint kinase chk1. In turn, the tumor suppressor p53 interacts with p21 to block the activity of cdk2 (cyclin dependent kinase 2) preventing passage from G1 to S phase and harmful replication of damaged DNA. One of the targets of cdk2 is the Rb gene product, another tumor suppressor. When dephosphorylated, Rb interacts with E2F transcription factors and prevents transcription of genes required for progression through the cell cycle. When phosphorylated by cell cycle dependent kinases like cdk2 and cdk4, Rb no longer interacts with E2F and the cell cycle proceeds through the G1-S checkpoint. DNA damage also regulates the G2-M phase transition by acting on the cell cycle regulator cdc2.
PMID	
GEOID	
AUTHORS	
CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_rbPathway.gif
SOURCE_MEMBERS	AA810989,BM469215,BM665433,BM670623,NM_000051,NM_000075,NM_000321,NM_000546,NM_001114121,NM_001114122,NM_001126112,NM_001126113,NM_001126114,NM_001126115,NM_001126116,NM_001126117,NM_001126118,NM_001143976,NM_001170406,NM_001170407,NM_001244846,NM_001274,NM_001786,NM_001789,NM_001790,NM_001798,NM_003390,NM_003405,NM_004358,NM_004535,NM_021872,NM_021873,NM_022809,NM_033379,NM_052827,NM_201567
GENE_SYMBOLS	CDK2,TP53,,,ATM,CDK4,RB1,TP53,CHEK1,CHEK1,TP53,TP53,TP53,TP53,TP53,TP53,TP53,WEE1,CDK1,CDK1,CHEK1,CHEK1,CDK1,CDC25A,CDC25C,CDK2,WEE1,YWHAH,CDC25B,MYT1,CDC25B,CDC25B,CDC25C,CDK1,CDK2,CDC25A
FOUNDER_NAMES