STANDARD_NAME	BIOCARTA_RHO_PATHWAY
SYSTEMATIC_NAME	M1001
COLLECTION	C2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_RHO_PATHWAY
NAMESPACE	HUMAN_SEQ_ACCESSION
DESCRIPTION_BRIEF	Rho cell motility signaling pathway
DESCRIPTION_FULL	RhoA is a small G-protein in the Rho family that regulates cell morphology via actin cytoskeleton reorganization in response to extracellular signals. The majority of RhoA activations is due to disruption of intramolecular autoinhibitory interactions. Changes in cytoskeletal structure and other aspects of cell structure are involved in cell morphology. RhoA is activated by GEF factors, and repressed by GAPs. GEFs are guanine nucleotide exchange factors. GAPs are GTPase-activating proteins. The RhoGAP ARHGAP1 also acts as a GAP for Rac and CDC42. Active RhoA increases the stability of actin-based structures such as stress fibers and focal adhesions. Several different factors downstream of RhoA act on cytoskeletal structures to affect stability of these structures. Rock1 provides a direct link from RhoA to cell morphology through phosphorylation of the myosin light chain. Rock1 also phosphorylates and activates LIM kinase, which phosphorylates cofilin. Cofilin stimulates actin depolymerization and changes in cell structure, and phosphorylation of cofilin by LIM kinase represses this activity. According to Nimnual et al. Rho activity is reduced as a result of Rac-induced redox-dependent inhibition. Related Disease: Non-syndromic deafness appears to be the result of amino acid substitutions in the 52-amino acid C-terminal end of Dia 1. This modification creates a constituatively active Dia 1 protein. A mutation in the RhoGAP Oligophrenin-1 is thought to contribute to a form of mental retardation due to loss of Rho inhibition in neuronal development.
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GEOID	
AUTHORS	
CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_rhoPathway.gif
SOURCE_MEMBERS	AF085856,NM_000177,NM_000432,NM_001030055,NM_001079812,NM_001127662,NM_001127663,NM_001127664,NM_001127665,NM_001127666,NM_001127667,NM_001135636,NM_001135637,NM_001135638,NM_001144888,NM_001164741,NM_001167857,NM_001167858,NM_001173,NM_001197131,NM_001204426,NM_001258029,NM_001664,NM_001666,NM_002314,NM_002481,NM_002547,NM_003373,NM_003557,NM_003558,NM_004308,NM_004706,NM_005022,NM_005219,NM_005406,NM_005435,NM_006125,NM_006289,NM_006340,NM_013423,NM_013427,NM_014000,NM_014784,NM_017450,NM_017451,NM_032103,NM_032104,NM_198236,NM_198252,NM_198977,NM_199002
GENE_SYMBOLS	PIP5K1A,GSN,MYL2,ARHGAP5,DIAPH1,GSN,GSN,GSN,GSN,GSN,GSN,PIP5K1A,PIP5K1A,PIP5K1A,BAIAP2,ARHGAP4,PPP1R12B,PPP1R12B,ARHGAP5,PPP1R12B,LIMK1,GSN,RHOA,ARHGAP4,LIMK1,PPP1R12B,OPHN1,VCL,PIP5K1A,PIP5K1B,ARHGAP1,ARHGEF1,PFN1,DIAPH1,ROCK1,ARHGEF5,ARHGAP6,TLN1,BAIAP2,ARHGAP6,ARHGAP6,VCL,ARHGEF11,BAIAP2,BAIAP2,PPP1R12B,PPP1R12B,ARHGEF11,GSN,ARHGEF1,ARHGEF1
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