STANDARD_NAME	BIOCARTA_STATHMIN_PATHWAY
SYSTEMATIC_NAME	M16966
COLLECTION	C2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_STATHMIN_PATHWAY
NAMESPACE	Human_RefSeq
DESCRIPTION_BRIEF	Stathmin and breast cancer resistance to antimicrotubule agents
DESCRIPTION_FULL	Stathmin is a ubiquitous, cytosolic 19-kDa protein, which is phosphorylated on up to four sites in response to many regulatory signals within cells. Its molecular characterization indicates a functional organization including an N-terminal regulatory domain that bears the phosphorylation sites, linked to a putative alpha-helical binding domain predicted to participate in coiled-coil, protein-protein interactions. In addtion to the protein kinases that phospjhorylate Stathmin such as CaMK, MAPK, p34cdc2, PKA, a few other proteins have been suggested to interact with stathmin in vivo. One of them was identified as BiP, a member of the hsp70 heat-shock protein family. Another is a previously unidentified, putative serine/threonine kinase, KIS, which might be regulated by stathmin or, more likely, be part of the kinases controlling its phosphorylation state. Finally, two proteins, CC1 and CC2, predicted to form alpha-helices participating in coiled-coil interacting structures. It has been also suggest that the action of antimicrotubule drugs can be affected by stathmin in at least two ways: (a) altered drug binding; and (b) growth arrest at the G2 to M boundary. Mutant p53 breast cancers exhibiting high levels of stathmin may be resistant to antimicrotubule agents.
PMID	
GEOID	
AUTHORS	
CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_stathminPathway.gif
SOURCE_MEMBERS	NM_000073,NM_000732,NM_000733,NM_000734,NM_001040651,NM_001083617,NM_001145454,NM_001164758,NM_001164759,NM_001164760,NM_001164761,NM_001164762,NM_001170406,NM_001170407,NM_001184763,NM_001242857,NM_001242858,NM_001242859,NM_001242860,NM_001242861,NM_001242862,NM_001744,NM_001767,NM_001786,NM_002731,NM_002732,NM_002734,NM_002735,NM_002736,NM_002754,NM_004157,NM_005347,NM_005563,NM_006292,NM_014781,NM_031966,NM_033379,NM_144624,NM_175866,NM_182948,NM_198053,NM_203399,NM_203401,NM_207578,NM_212471,NM_212472
GENE_SYMBOLS	CD3G,CD3D,CD3E,CD247,CD3D,RB1CC1,STMN1,PRKAR1B,PRKAR1B,PRKAR1B,PRKAR1B,PRKAR1B,CDK1,CDK1,UHMK1,PRKACB,PRKACB,PRKACB,PRKACB,PRKACB,PRKACB,CAMK4,CD2,CDK1,PRKACB,PRKACG,PRKAR1A,PRKAR1B,PRKAR2B,MAPK13,PRKAR2A,HSPA5,STMN1,TSG101,RB1CC1,CCNB1,CDK1,UHMK1,UHMK1,PRKACB,CD247,STMN1,STMN1,PRKACB,PRKAR1A,PRKAR1A
FOUNDER_NAMES