STANDARD_NAME	BIOCARTA_TGFB_PATHWAY
SYSTEMATIC_NAME	M18933
COLLECTION	C2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_TGFB_PATHWAY
NAMESPACE	HUMAN_SEQ_ACCESSION
DESCRIPTION_BRIEF	TGF beta signaling pathway
DESCRIPTION_FULL	TGF-beta regulates growth and proliferation of cells, blocking growth of many cell types. The TGF-beta receptor includes type 1 and type 2 subunits that are serine-threonine kinases and that signal through the SMAD family of transcriptional regulators. Defects in TGF-beta signaling, includes mutation in SMADs, have been associated with cancer in humans. Prior to activation, receptor regulated SMADs are anchored to the cell membrane by factors like SARA (SMAD Anchor for Receptor Activation) that brings the SMADs into proximity of the TGF receptor kinases. Binding of TGF induces phosphorylation and activation of the TGF-beta R1 receptor by the TGF-beta R2 receptor. The activated TGF-beta R1 phosphorylates SMAD2 and SMAD3, which bind to the SMAD4 mediator to move into the nucleus and form complexes that regulate transcription. SMADs regulate transcription in several ways, including binding to DNA, interacting with other transcription factors, and interacting with transcription corepressors and coactivators like p300 and CBP. SMAD-7 represses signaling by other SMADs to down-regulate the system. Other signaling pathways like the MAP kinase-ERK cascade are activated by TGF-beta signaling, modulate SMAD activation. SnoN also regulates TGF-beta signaling, by binding to SMADs to block transcriptional activation. TGF-beta signaling causes degradation of SnoN, releasing SMADs to regulate transcription, and also activates expression of SnoN, to down-regulate SMAD signaling at later times.
PMID	
GEOID	
AUTHORS	
CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_tgfbPathway.gif
SOURCE_MEMBERS	AI279872,AL706144,BU686912,BX459012,JX103164,NM_000038,NM_000660,NM_001003652,NM_001024847,NM_001040056,NM_001079846,NM_001109891,NM_001127510,NM_001127511,NM_001130916,NM_001135599,NM_001135937,NM_001145097,NM_001145098,NM_001145102,NM_001145103,NM_001145104,NM_001190821,NM_001190822,NM_001190823,NM_001248008,NM_001429,NM_002746,NM_002755,NM_003188,NM_003238,NM_003239,NM_003242,NM_004360,NM_004380,NM_004612,NM_004799,NM_005359,NM_005414,NM_005901,NM_005902,NM_005904,NM_006116,NM_007323,NM_007324,NM_145331,NM_145332,NM_145333,NM_153497
GENE_SYMBOLS	TGFBR2,,SMAD3,,SKIL,APC,TGFB1,SMAD2,TGFBR2,MAPK3,CREBBP,MAPK3,APC,APC,TGFBR1,TGFB2,SMAD2,SKIL,SKIL,SMAD3,SMAD3,SMAD3,SMAD7,SMAD7,SMAD7,SKIL,EP300,MAPK3,MAP2K1,MAP3K7,TGFB2,TGFB3,TGFBR2,CDH1,CREBBP,TGFBR1,ZFYVE9,SMAD4,SKIL,SMAD2,SMAD3,SMAD7,TAB1,ZFYVE9,ZFYVE9,MAP3K7,MAP3K7,MAP3K7,TAB1
FOUNDER_NAMES