STANDARD_NAME	BIOCARTA_TRKA_PATHWAY
SYSTEMATIC_NAME	M9134
COLLECTION	C2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_TRKA_PATHWAY
NAMESPACE	HUMAN_SEQ_ACCESSION
DESCRIPTION_BRIEF	Trka Receptor Signaling Pathway
DESCRIPTION_FULL	Nerve growth factor (NGF) is a neurotrophic factor that stimulates neuronal survival and growth through TrkA, a member of the trk family of tyrosine kinase receptors that also includes TrkB and TrkC. Some NGF responses are also mediated or modified by p75LNTR, a low affinity neurotrophin receptor. Binding of NGF to TrkA stimulates neuronal survival, and also proliferation. Pathways coupled to these responses are linked to TrkA through association of signaling factors with specific amino acids in the TrkA cytoplasmic domain. Cell survival through inhibition of apoptosis is signaled through activation of PI3-kinase and AKT. Ras-mediated signaling and phospholipase C both activate the MAP kinase pathway to stimulate proliferation.
PMID	
GEOID	
AUTHORS	
CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_trkaPathway.gif
SOURCE_MEMBERS	AI334281,AK021510,AK055431,AL833457,BM458681,NM_001002231,NM_001007792,NM_001012331,NM_001014431,NM_001014432,NM_001130040,NM_001130041,NM_001130442,NM_001202859,NM_001242466,NM_001256080,NM_002086,NM_002506,NM_002529,NM_002660,NM_002737,NM_002738,NM_003029,NM_003863,NM_005163,NM_005343,NM_005551,NM_005633,NM_006218,NM_176795,NM_181504,NM_181523,NM_181524,NM_182811,NM_183001,NM_203506,NM_212535
GENE_SYMBOLS	PIK3R1,PIK3CA,PRKCA,SOS1,,KLK2,NTRK1,NTRK1,AKT1,AKT1,SHC1,SHC1,HRAS,SHC1,PIK3R1,KLK2,GRB2,NGF,NTRK1,PLCG1,PRKCA,PRKCB,SHC1,DPM2,AKT1,HRAS,KLK2,SOS1,PIK3CA,HRAS,PIK3R1,PIK3R1,PIK3R1,PLCG1,SHC1,GRB2,PRKCB
FOUNDER_NAMES