STANDARD_NAME	BIOCARTA_UCALPAIN_PATHWAY
SYSTEMATIC_NAME	M13143
COLLECTION	C2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_UCALPAIN_PATHWAY
NAMESPACE	Human_RefSeq
DESCRIPTION_BRIEF	uCalpain and friends in Cell spread
DESCRIPTION_FULL	The mammalian calpain gene family curently contains 13 distinct large subunit products most of which complex with one of two smaller 30kDa subunits. ( An excellent introduction to the Calpain family can be found on a web site created by Valery Thompson http://ag.arizona.edu/calpains/index.html ) Spreading cells display newly transiently formed integrin adhesion clusters containing Calpain1 (mu-Calpain), cleaved Talin, B3-Integrin and SPTAN1(Spectrin). Recruitment of Rac to these clusters leads to the activation of Rac and the formation of Rac-induced Focal clusters. The Calpain1 in the integrin clusters initially inactivates RhoA allowing for the formation of lamellipodia. The subsequent activation of newly synthesized RhoA transforms these clusters into Focal Adhesion Complexes and the formation of contractile actin-myosin stress fibers. These mature adhesions do not contain calpain.
PMID	
GEOID	
AUTHORS	
CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_uCalpainPathway.gif
SOURCE_MEMBERS	DC369297,NM_000212,NM_001003962,NM_001100,NM_001102,NM_001103,NM_001104,NM_001111077,NM_001130004,NM_001130005,NM_001130438,NM_001195532,NM_001198868,NM_001198869,NM_001258371,NM_001664,NM_001749,NM_002211,NM_003127,NM_003379,NM_005186,NM_006289,NM_006908,NM_018890,NM_032330,NM_033668,NM_133376
GENE_SYMBOLS	,ITGB3,CAPNS1,ACTA1,ACTN1,ACTN2,ACTN3,EZR,ACTN1,ACTN1,SPTAN1,SPTAN1,CAPN1,CAPN1,ACTN3,RHOA,CAPNS1,ITGB1,SPTAN1,EZR,CAPN1,TLN1,RAC1,RAC1,CAPNS2,ITGB1,ITGB1
FOUNDER_NAMES