STANDARD_NAME	BIOCARTA_VIP_PATHWAY
SYSTEMATIC_NAME	M17941
COLLECTION	C2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_VIP_PATHWAY
NAMESPACE	HUMAN_SEQ_ACCESSION
DESCRIPTION_BRIEF	Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells
DESCRIPTION_FULL	Vasoactive intestinal peptide (VIP) and the structurally related pituitary adenylate cyclase-activating polypeptide (PACAP), two neuropeptides present in the lymphoid microenvironment, elicit a broad spectrum of biological functions, including the modulation of innate and adaptive immunity. Another important immunoregulatory function of VIP and PACAP is their inhibition effect on AICD in T cells. They inhibit the TCR-stimulated FasL expression and apoptosis of T cell through specific receptors and induction of intracellular cAMP. VIP down-regulate c-Myc synthesis, the NF-AT-dependent Egr2 and Egr3 expression, the NF-AT and NF-kB.
PMID	
GEOID	
AUTHORS	
CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_vipPathway.gif
SOURCE_MEMBERS	BC045628,BQ218507,NM_000399,NM_000944,NM_001130691,NM_001130692,NM_001136021,NM_001136177,NM_001136178,NM_001136179,NM_001142353,NM_001142354,NM_001145138,NM_001164758,NM_001164759,NM_001164760,NM_001164761,NM_001164762,NM_001165412,NM_001199880,NM_001199881,NM_001242857,NM_001242858,NM_001242859,NM_001242860,NM_001242861,NM_001242862,NM_001243974,NM_001243975,NM_001243984,NM_001243985,NM_001258292,NM_001258294,NM_001258295,NM_001258296,NM_001258297,NM_001278,NM_001743,NM_002072,NM_002467,NM_002660,NM_002731,NM_002732,NM_002734,NM_002735,NM_002736,NM_003381,NM_003382,NM_003998,NM_004157,NM_004430,NM_005184,NM_005605,NM_005921,NM_006162,NM_006888,NM_012340,NM_020529,NM_021132,NM_021975,NM_172387,NM_172388,NM_172389,NM_172390,NM_173091,NM_182811,NM_182948,NM_194435,NM_207578,NM_212471,NM_212472
GENE_SYMBOLS	NFATC1,CALM1,EGR2,PPP3CA,PPP3CA,PPP3CA,NFATC2,EGR2,EGR2,EGR2,PPP3CB,PPP3CB,RELA,PRKAR1B,PRKAR1B,PRKAR1B,PRKAR1B,PRKAR1B,NFKB1,EGR3,EGR3,PRKACB,PRKACB,PRKACB,PRKACB,PRKACB,PRKACB,PPP3CC,PPP3CC,RELA,RELA,NFATC2,NFATC2,NFATC2,NFATC2,NFATC2,CHUK,CALM2,GNAQ,MYC,PLCG1,PRKACB,PRKACG,PRKAR1A,PRKAR1B,PRKAR2B,VIP,VIPR2,NFKB1,PRKAR2A,EGR3,CALM3,PPP3CC,MAP3K1,NFATC1,CALM1,NFATC2,NFKBIA,PPP3CB,RELA,NFATC1,NFATC1,NFATC1,NFATC1,NFATC2,PLCG1,PRKACB,VIP,PRKACB,PRKAR1A,PRKAR1A
FOUNDER_NAMES